Cell atlas - MCOLN3 - The Human Protein Atlas

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MCOLN3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli

Human cell
	Cytosol
	Nucleoli

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GENERAL INFORMATION
Gene name	MCOLN3
Gene description	Mucolipin 3
Protein class	Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli & cytosol.
RNA cell category	Cell line enhanced (SK-MEL-30, RH-30, BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA018106
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-MEL-30, RH-30, BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli & cytosol.

Main location

Nucleoli (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA018106	A-431	Cytosol
	HPA018106	HEK 293	Nucleoli
	HPA018106	HEK 293	Cytosol
	HPA018106	U-2 OS	Nucleoli
	HPA018106	U-2 OS	Cytosol

GENE INFORMATION
Gene name	MCOLN3 (HGNC Symbol)
Synonyms	FLJ11006, TRP-ML3, TRPML3
Description	Mucolipin 3 (HGNC Symbol)
Entrez gene summary	This gene encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	1
Cytoband	p22.3
Chromosome location (bp)	85018082 - 85048499
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000055732 (version 83.38)
Entrez gene	55283
UniProt	Q8TDD5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TDD5
Antibodypedia	MCOLN3 antibodies

PROTEIN BROWSER

MCOLN3-001	MCOLN3-002	MCOLN3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MCOLN3-001 ENSP00000359621 ENST00000370589	Q8TDD5 [Direct mapping] Mucolipin-3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007626 [locomotory behavior] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0042491 [auditory receptor cell differentiation] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	553 aa 64.2 kDa	No	6
MCOLN3-002 ENSP00000342698 ENST00000341115	Q8TDD5 [Direct mapping] Mucolipin-3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	497 aa 57.7 kDa	No	5
MCOLN3-006 ENSP00000359619 ENST00000370587	B1ANB7 [Direct mapping] Mucolipin 3, isoform CRA_d; Mucolipin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	321 aa 37.2 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.