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GDI2

CANCER ATLAS

Gene description

 GDP dissociation inhibitor 2

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049290
HPA057668

GENE INFORMATION

Gene name

 GDI2 (HGNC Symbol)

Synonyms

 RABGDIB

Description

 GDP dissociation inhibitor 2 (HGNC Symbol)

Entrez gene summary

 GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 5765223 - 5842132

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000057608 (version 83.38)

Entrez gene

 2665

UniProt

 P50395 (UniProt - Evidence at protein level)

neXtProt

 NX_P50395

Antibodypedia

 GDI2 antibodies

PROTEIN BROWSER
GDI2-001
GDI2-002
GDI2-003
GDI2-004
GDI2-005
GDI2-007
GDI2-008
GDI2-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GDI2-001
ENSP00000369538
ENST00000380191
P50395 [Direct mapping]
Rab GDP dissociation inhibitor beta
Q6IAT1 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 46e; GDI2 protein; GDP dissociation inhibitor 2 isoform 1; GDP dissociation inhibitor 2, isoform CRA_b; cDNA, FLJ92845, Homo sapiens GDP dissociation inhibitor 2 (GDI2), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005093 [Rab GDP-dissociation inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0031267 [small GTPase binding]
GO:0031982 [vesicle]
GO:0043209 [myelin sheath]
GO:0043547 [positive regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0050790 [regulation of catalytic activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
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 445 aa
50.7 kDa 		No 0
GDI2-002
ENSP00000369528
ENST00000380181
P50395 [Direct mapping]
Rab GDP dissociation inhibitor beta
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0031982 [vesicle]
GO:0043547 [positive regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
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 400 aa
45.6 kDa 		No 0
GDI2-003
ENSP00000387565
ENST00000447751
Q5SX91 [Direct mapping]
Rab GDP dissociation inhibitor beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005093 [Rab GDP-dissociation inhibitor activity]
GO:0015031 [protein transport]
GO:0050790 [regulation of catalytic activity]
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 203 aa
23.1 kDa 		No 0
GDI2-004
ENSP00000394177
ENST00000418688
Q5SX86 [Direct mapping]
Rab GDP dissociation inhibitor beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005093 [Rab GDP-dissociation inhibitor activity]
GO:0015031 [protein transport]
GO:0050790 [regulation of catalytic activity]
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 155 aa
17.8 kDa 		No 0
GDI2-005
ENSP00000401733
ENST00000456041
Q5SX87 [Direct mapping]
Rab GDP dissociation inhibitor beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005093 [Rab GDP-dissociation inhibitor activity]
GO:0015031 [protein transport]
GO:0050790 [regulation of catalytic activity]
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 263 aa
29.9 kDa 		No 0
GDI2-007
ENSP00000369470
ENST00000380127
Q5SX90 [Direct mapping]
Rab GDP dissociation inhibitor beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005093 [Rab GDP-dissociation inhibitor activity]
GO:0015031 [protein transport]
GO:0050790 [regulation of catalytic activity]
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 148 aa
16.8 kDa 		No 0
GDI2-008
ENSP00000476707
ENST00000608581
V9GYF8 [Direct mapping]
Rab GDP dissociation inhibitor beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005093 [Rab GDP-dissociation inhibitor activity]
GO:0015031 [protein transport]
GO:0050790 [regulation of catalytic activity]
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 130 aa
14.9 kDa 		No 0
GDI2-009
ENSP00000476832
ENST00000609712
V9GYJ7 [Direct mapping]
Rab GDP dissociation inhibitor beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005093 [Rab GDP-dissociation inhibitor activity]
GO:0015031 [protein transport]
GO:0050790 [regulation of catalytic activity]
Show all
 126 aa
14.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.