Cell atlas - MTA3 - The Human Protein Atlas

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MTA3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	MTA3
Gene description	Metastasis associated 1 family, member 3
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to vesicles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA039433
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to vesicles.

Main location

Nucleus (supported)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039433	A-431	Nucleus
	HPA039433	A-431	Vesicles
	HPA039433	U-2 OS	Nucleoplasm
	HPA039433	U-2 OS	Vesicles
	HPA039433	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	MTA3 (HGNC Symbol)
Synonyms	KIAA1266
Description	Metastasis associated 1 family, member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p21
Chromosome location (bp)	42494569 - 42756947
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000057935 (version 83.38)
Entrez gene	57504
UniProt	Q9BTC8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BTC8
Antibodypedia	MTA3 antibodies

PROTEIN BROWSER

MTA3-001	MTA3-002	MTA3-003	MTA3-005	MTA3-011	MTA3-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTA3-001 ENSP00000384249 ENST00000406652	D6W5A2 [Direct mapping] Metastasis associated 1 family, member 3, isoform CRA_a; Metastasis-associated protein MTA3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] Show all	537 aa 60.9 kDa	No	0
MTA3-002 ENSP00000385045 ENST00000407270	Q9BTC8 [Direct mapping] Metastasis-associated protein MTA3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	515 aa 58.8 kDa	No	0
MTA3-003 ENSP00000385241 ENST00000406911	E7EQY4 [Direct mapping] Metastasis-associated protein MTA3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] Show all	514 aa 58.7 kDa	No	0
MTA3-005 ENSP00000383973 ENST00000405592	D6W5A2 [Direct mapping] Metastasis associated 1 family, member 3, isoform CRA_a; Metastasis-associated protein MTA3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0008278 [cohesin complex] GO:0008284 [positive regulation of cell proliferation] GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] GO:0016581 [NuRD complex] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] Show all	537 aa 60.9 kDa	No	0
MTA3-011 ENSP00000388722 ENST00000433553	C9JR73 [Direct mapping] Metastasis-associated protein MTA3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		18 aa 2.1 kDa	No	0
MTA3-017 ENSP00000385823 ENST00000405094	Q9BTC8 [Direct mapping] Metastasis-associated protein MTA3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	594 aa 67.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.