Tissue expression of SEC61A1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SEC61A1
Gene description	Sec61 translocon alpha 1 subunit
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SEC61A1
Synonyms
Description	Sec61 translocon alpha 1 subunit (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q21.3
Chromosome location (bp)	128051641 - 128071683
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000058262 (version 83.38)
Entrez gene	29927
UniProt	P61619 (UniProt - Evidence at protein level)
neXtProt	NX_P61619
Antibodypedia	SEC61A1 antibodies

PROTEIN BROWSER

SEC61A1-001	SEC61A1-002	SEC61A1-003	SEC61A1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEC61A1-001 ENSP00000243253 ENST00000243253	P61619 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 1 B3KNF6 [Target identity:100%; Query identity:100%] Sec61 alpha 1 subunit (S. cerevisiae), isoform CRA_c; cDNA FLJ14517 fis, clone NT2RM1000833, highly similar to Protein transport protein Sec61 subunit alpha isoform 1; cDNA FLJ90225 fis, clone NT2RM1000855, highly similar to Protein transport protein Sec61 subunit alpha isoform 1 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005791 [rough endoplasmic reticulum] GO:0005829 [cytosol] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006620 [posttranslational protein targeting to membrane] GO:0007029 [endoplasmic reticulum organization] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016049 [cell growth] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0034341 [response to interferon-gamma] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0043022 [ribosome binding] GO:0044267 [cellular protein metabolic process] GO:0045047 [protein targeting to ER] Show all	476 aa 52.3 kDa	No	9
SEC61A1-002 ENSP00000418493 ENST00000464451	B4DR61 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 1; cDNA FLJ59739, highly similar to Protein transport protein Sec61 subunit alpha isoform 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	482 aa 52.9 kDa	No	9
SEC61A1-003 ENSP00000411445 ENST00000424880	P61619 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 1 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006620 [posttranslational protein targeting to membrane] GO:0007029 [endoplasmic reticulum organization] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016049 [cell growth] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0043022 [ribosome binding] GO:0044267 [cellular protein metabolic process] GO:0045047 [protein targeting to ER] Show all	356 aa 38.8 kDa	No	6
SEC61A1-005 ENSP00000419172 ENST00000481210	C9JXC6 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	101 aa 10.8 kDa	No	2