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RASGRF1

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GENERAL INFORMATION

Gene name

 RASGRF1

Gene description

 Ras protein-specific guanine nucleotide-releasing factor 1

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the Golgi apparatus.

RNA cell category

 Cell line enhanced (U-2 OS, RPMI-8226, BEWO, Karpas-707, A-431)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
CAB010413 , HPA041965
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2 OS, RPMI-8226, BEWO, Karpas-707, A-431)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the Golgi apparatus.

Main location

 Golgi apparatus (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB010413 A-431 Golgi apparatus
CAB010413 U-2 OS Golgi apparatus
CAB010413 U-251 MG Golgi apparatus
HPA041965 A-431 Nucleus
Golgi apparatus
HPA041965 U-2 OS Nuclear speckles
Golgi apparatus
HPA041965 U-251 MG Nucleoplasm
Golgi apparatus

GENE INFORMATION

Gene name

 RASGRF1 (HGNC Symbol)

Synonyms

 CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187

Description

 Ras protein-specific guanine nucleotide-releasing factor 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

Chromosome

 15

Cytoband

 q25.1

Chromosome location (bp)

 78959947 - 79090773

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000058335 (version 83.38)

Entrez gene

 5923

UniProt

 Q13972 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13972

Antibodypedia

 RASGRF1 antibodies

PROTEIN BROWSER
RASGRF1-001
RASGRF1-002
RASGRF1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASGRF1-001
ENSP00000405963
ENST00000419573
Q13972 [Direct mapping]
Ras-specific guanine nucleotide-releasing factor 1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007616 [long-term memory]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0030426 [growth cone]
GO:0031175 [neuron projection development]
GO:0035020 [regulation of Rac protein signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035254 [glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048167 [regulation of synaptic plasticity]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0090630 [activation of GTPase activity]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 1273 aa
145.2 kDa 		No 0
RASGRF1-002
ENSP00000452781
ENST00000558480
Q13972 [Direct mapping]
Ras-specific guanine nucleotide-releasing factor 1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007616 [long-term memory]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0030426 [growth cone]
GO:0031175 [neuron projection development]
GO:0035020 [regulation of Rac protein signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048167 [regulation of synaptic plasticity]
GO:0090630 [activation of GTPase activity]
Show all
 1257 aa
143.2 kDa 		No 0
RASGRF1-003
ENSP00000378228
ENST00000394745
Q13972 [Direct mapping]
Ras-specific guanine nucleotide-releasing factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007616 [long-term memory]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0030426 [growth cone]
GO:0031175 [neuron projection development]
GO:0035020 [regulation of Rac protein signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048167 [regulation of synaptic plasticity]
GO:0090630 [activation of GTPase activity]
Show all
 489 aa
55.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.