Cell atlas - DGKG - The Human Protein Atlas

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DGKG

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane
	Vesicles

Human cell
	Plasma Membrane
	Vesicles

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GENERAL INFORMATION
Gene name	DGKG
Gene description	Diacylglycerol kinase, gamma 90kDa
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & vesicles.
RNA cell category	Cell line enhanced (HDLM-2, U-87 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved), Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036577
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, U-87 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & vesicles.

Main location

Vesicles (approved), Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036577	A-431	Vesicles
	HPA036577	A-431	Plasma membrane
	HPA036577	U-2 OS	Vesicles
	HPA036577	U-2 OS	Plasma membrane
	HPA036577	U-251 MG	Vesicles
	HPA036577	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	DGKG (HGNC Symbol)
Synonyms	DAGK3
Description	Diacylglycerol kinase, gamma 90kDa (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband
Chromosome location (bp)	186105668 - 186362237
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000058866 (version 83.38)
Entrez gene	1608
UniProt	P49619 (UniProt - Evidence at transcript level)
neXtProt	NX_P49619
Antibodypedia	DGKG antibodies

PROTEIN BROWSER

DGKG-001	DGKG-003	DGKG-004	DGKG-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DGKG-001 ENSP00000265022 ENST00000265022	P49619 [Direct mapping] Diacylglycerol kinase gamma Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0030168 [platelet activation] GO:0035556 [intracellular signal transduction] GO:0043231 [intracellular membrane-bounded organelle] GO:0048666 [neuron development] Show all	791 aa 89.1 kDa	No	0
DGKG-003 ENSP00000371599 ENST00000382164	P49619 [Direct mapping] Diacylglycerol kinase gamma Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0030168 [platelet activation] GO:0035556 [intracellular signal transduction] GO:0043231 [intracellular membrane-bounded organelle] Show all	752 aa 84.6 kDa	No	0
DGKG-004 ENSP00000339777 ENST00000344484	P49619 [Direct mapping] Diacylglycerol kinase gamma Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0030168 [platelet activation] GO:0035556 [intracellular signal transduction] GO:0043231 [intracellular membrane-bounded organelle] Show all	766 aa 86.3 kDa	No	0
DGKG-011 ENSP00000395526 ENST00000437018	H7C0L0 [Direct mapping] Diacylglycerol kinase gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	154 aa 17.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.