Cell atlas - UNKL - The Human Protein Atlas

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UNKL

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	UNKL
Gene description	Unkempt family zinc finger-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA073949
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA073949	A549	Cytosol
	HPA073949	PC-3	Cytosol
	HPA073949	U-2 OS	Cytosol

GENE INFORMATION
Gene name	UNKL (HGNC Symbol)
Synonyms	C16orf28, FLJ23360, ZC3H5L, ZC3HDC5L
Description	Unkempt family zinc finger-like (HGNC Symbol)
Entrez gene summary	This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	1363205 - 1414751
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000059145 (version 83.38)
Entrez gene	64718
UniProt	Q9H9P5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H9P5
Antibodypedia	UNKL antibodies

PROTEIN BROWSER

UNKL-001	UNKL-002	UNKL-009	UNKL-010	UNKL-019	UNKL-201	UNKL-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UNKL-001 ENSP00000301712 ENST00000301712	Q9H9P5 [Direct mapping] Putative E3 ubiquitin-protein ligase UNKL Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0046872 [metal ion binding] Show all	277 aa 31.8 kDa	No	0
UNKL-002 ENSP00000422852 ENST00000508903	E9PDK2 [Direct mapping] Putative E3 ubiquitin-protein ligase UNKL Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	733 aa 79.5 kDa	No	0
UNKL-009 ENSP00000380606 ENST00000397464	Q9H9P5 [Direct mapping] Putative E3 ubiquitin-protein ligase UNKL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	182 aa 20 kDa	No	0
UNKL-010 ENSP00000423107 ENST00000513783	D6RA68 [Direct mapping] Putative E3 ubiquitin-protein ligase UNKL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 7.6 kDa	No	0
UNKL-019 ENSP00000384850 ENST00000402641	A0A0A0MSC7 [Direct mapping] Putative E3 ubiquitin-protein ligase UNKL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 12.3 kDa	No	0
UNKL-201 ENSP00000248104 ENST00000248104	Q9H9P5 [Direct mapping] Putative E3 ubiquitin-protein ligase UNKL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	229 aa 25.2 kDa	No	0
UNKL-202 ENSP00000373873 ENST00000389221	A0A0A0MRZ1 [Direct mapping] Putative E3 ubiquitin-protein ligase UNKL Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	683 aa 74.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.