Expression of TBXAS1 in cancer - Summary

CANCER ATLAS

Gene description

Thromboxane A synthase 1 (platelet)

Protein class

Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA031257	HPA031258	HPA031259

GENE INFORMATION
Gene name	TBXAS1 (HGNC Symbol)
Synonyms	CYP5, CYP5A1, THAS, TS, TXAS, TXS
Description	Thromboxane A synthase 1 (platelet) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	139777051 - 140020325
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000059377 (version 83.38)
Entrez gene	6916
UniProt	P24557 (UniProt - Evidence at protein level)
neXtProt	NX_P24557
Antibodypedia	TBXAS1 antibodies

PROTEIN BROWSER

TBXAS1-001	TBXAS1-002	TBXAS1-003	TBXAS1-004	TBXAS1-005	TBXAS1-008	TBXAS1-011	TBXAS1-201	TBXAS1-202	TBXAS1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBXAS1-001 ENSP00000338087 ENST00000336425	P24557 [Direct mapping] Thromboxane-A synthase Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0004796 [thromboxane-A synthase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006690 [icosanoid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	533 aa 60.5 kDa	No	2
TBXAS1-002 ENSP00000388736 ENST00000425687	P24557 [Direct mapping] Thromboxane-A synthase Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0004796 [thromboxane-A synthase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006690 [icosanoid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	466 aa 53 kDa	No	0
TBXAS1-003 ENSP00000402536 ENST00000448866	P24557 [Direct mapping] Thromboxane-A synthase Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0004796 [thromboxane-A synthase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006690 [icosanoid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	533 aa 60.5 kDa	No	2
TBXAS1-004 ENSP00000411274 ENST00000458722	P24557 [Direct mapping] Thromboxane-A synthase Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0004796 [thromboxane-A synthase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006690 [icosanoid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	579 aa 65.6 kDa	No	2
TBXAS1-005 ENSP00000411326 ENST00000411653	P24557 [Direct mapping] Thromboxane-A synthase Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0004796 [thromboxane-A synthase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006690 [icosanoid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	459 aa 52.3 kDa	No	1
TBXAS1-008 ENSP00000391567 ENST00000455353	E7EP75 [Direct mapping] Thromboxane-A synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	151 aa 17.3 kDa	No	1
TBXAS1-011 ENSP00000388612 ENST00000438104	C9JS68 [Direct mapping] Thromboxane-A synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	150 aa 17.2 kDa	No	1
TBXAS1-201 ENSP00000263552 ENST00000263552	Q53F23 [Direct mapping] HCG14925, isoform CRA_a; Thromboxane A synthase 1 (Platelet, cytochrome P450, family 5, subfamily A) isoform TXS-I variant; Thromboxane-A synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	534 aa 60.6 kDa	No	2
TBXAS1-202 ENSP00000392702 ENST00000414508	A0A0A0MSK3 [Direct mapping] HCG14925, isoform CRA_b; Thromboxane-A synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	460 aa 52.4 kDa	No	1
TBXAS1-203 ENSP00000389414 ENST00000416849	A0A0C4DH47 [Direct mapping] Thromboxane-A synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0004796 [thromboxane-A synthase activity] GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0030644 [cellular chloride ion homeostasis] GO:0045907 [positive regulation of vasoconstriction] GO:0055114 [oxidation-reduction process] Show all	580 aa 65.8 kDa	No	2