Cell atlas - CDK17 - The Human Protein Atlas

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CDK17

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CDK17
Gene description	Cyclin-dependent kinase 17
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA015325
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA015325	A-431	Nucleoplasm	Spatial
	HPA015325	A-431	Cytosol	Spatial
	HPA015325	U-2 OS	Nucleoplasm	Spatial
	HPA015325	U-2 OS	Cytosol	Spatial
	HPA015325	U-251 MG	Nucleoplasm
	HPA015325	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CDK17 (HGNC Symbol)
Synonyms	PCTAIRE2, PCTK2
Description	Cyclin-dependent kinase 17 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Chromosome	12
Cytoband	q23.1
Chromosome location (bp)	96278261 - 96400560
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000059758 (version 83.38)
Entrez gene	5128
UniProt	Q00537 (UniProt - Evidence at protein level)
neXtProt	NX_Q00537
Antibodypedia	CDK17 antibodies

PROTEIN BROWSER

CDK17-001	CDK17-002	CDK17-003	CDK17-004	CDK17-005	CDK17-006	CDK17-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK17-001 ENSP00000261211 ENST00000261211	Q00537 [Direct mapping] Cyclin-dependent kinase 17 A0A024RBH0 [Target identity:100%; Query identity:100%] PCTAIRE protein kinase 2, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0051726 [regulation of cell cycle] Show all	523 aa 59.6 kDa	No	0
CDK17-002 ENSP00000444459 ENST00000543119	Q00537 [Direct mapping] Cyclin-dependent kinase 17 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0051726 [regulation of cell cycle] Show all	523 aa 59.5 kDa	No	0
CDK17-003 ENSP00000442926 ENST00000542666	F5H6Z0 [Direct mapping] Cyclin-dependent kinase 17 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	470 aa 53.5 kDa	No	0
CDK17-004 ENSP00000447282 ENST00000552496	F8VZY6 [Direct mapping] Cyclin-dependent kinase 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 18 kDa	No	0
CDK17-005 ENSP00000450058 ENST00000551816	F8VQZ9 [Direct mapping] Cyclin-dependent kinase 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		179 aa 20.2 kDa	No	0
CDK17-006 ENSP00000448132 ENST00000552262	F8VUX2 [Direct mapping] Cyclin-dependent kinase 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 9.9 kDa	No	0
CDK17-007 ENSP00000447441 ENST00000548734	F8W1S5 [Direct mapping] Cyclin-dependent kinase 17 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 14.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.