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CTDP1

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GENERAL INFORMATION

Gene name

 CTDP1

Gene description

 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles. In addition localized to the actin filaments.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (supported)

Additional location

 In addition localized to the Actin filaments (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA040394
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles. In addition localized to the actin filaments.

Main location

 Nuclear speckles (supported)

Additional location

 Actin filaments (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA040394 A-431 Nuclear speckles
Actin filaments Intensity
HPA040394 U-2 OS Nuclear speckles
Actin filaments
HPA040394 U-251 MG Nuclear speckles

GENE INFORMATION

Gene name

 CTDP1 (HGNC Symbol)

Synonyms

 FCP1

Description

 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 18

Cytoband

 q23

Chromosome location (bp)

 79679801 - 79756623

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000060069 (version 83.38)

Entrez gene

 9150

UniProt

 Q9Y5B0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5B0

Antibodypedia

 CTDP1 antibodies

PROTEIN BROWSER
CTDP1-001
CTDP1-002
CTDP1-003
CTDP1-005
CTDP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTDP1-001
ENSP00000484525
ENST00000613122
Q9Y5B0 [Direct mapping]
RNA polymerase II subunit A C-terminal domain phosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006470 [protein dephosphorylation]
GO:0008420 [CTD phosphatase activity]
GO:0010458 [exit from mitosis]
GO:0010467 [gene expression]
GO:0015629 [actin cytoskeleton]
GO:0016032 [viral process]
GO:0030496 [midbody]
GO:0050434 [positive regulation of viral transcription]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0061052 [negative regulation of cell growth involved in cardiac muscle cell development]
Show all
 961 aa
104.4 kDa 		No 0
CTDP1-002
ENSP00000075430
ENST00000075430
Q9Y5B0 [Direct mapping]
RNA polymerase II subunit A C-terminal domain phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006470 [protein dephosphorylation]
GO:0008420 [CTD phosphatase activity]
GO:0010458 [exit from mitosis]
GO:0010467 [gene expression]
GO:0015629 [actin cytoskeleton]
GO:0016032 [viral process]
GO:0030496 [midbody]
GO:0050434 [positive regulation of viral transcription]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
Show all
 867 aa
93.5 kDa 		No 0
CTDP1-003
ENSP00000465119
ENST00000591598
K7EJD2 [Direct mapping]
RNA polymerase II subunit A C-terminal domain phosphatase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006470 [protein dephosphorylation]
GO:0015629 [actin cytoskeleton]
Show all
 799 aa
87.6 kDa 		No 0
CTDP1-005
ENSP00000467563
ENST00000590635
K7EPW4 [Direct mapping]
RNA polymerase II subunit A C-terminal domain phosphatase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0015629 [actin cytoskeleton]
Show all
 78 aa
8.7 kDa 		No 0
CTDP1-201
ENSP00000299543
ENST00000299543
A0A0A0MR03 [Direct mapping]
RNA polymerase II subunit A C-terminal domain phosphatase
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005634 [nucleus]
GO:0006470 [protein dephosphorylation]
Show all
 842 aa
92.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.