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WNK lysine deficient protein kinase 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0003084 [positive regulation of systemic arterial blood pressure] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004860 [protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006811 [ion transport] GO:0010923 [negative regulation of phosphatase activity] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019869 [chloride channel inhibitor activity] GO:0019870 [potassium channel inhibitor activity] GO:0019901 [protein kinase binding] GO:0019902 [phosphatase binding] GO:0030291 [protein serine/threonine kinase inhibitor activity] GO:0033673 [negative regulation of kinase activity] GO:0035556 [intracellular signal transduction] GO:0046777 [protein autophosphorylation] GO:0048666 [neuron development] GO:0050794 [regulation of cellular process] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:0090188 [negative regulation of pancreatic juice secretion] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
