Fields »
ABOUT
HELP
BLOG
CREB3L3

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 CREB3L3

Gene description

 CAMP responsive element binding protein 3-like 3

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HDLM-2, Hep G2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CREB3L3 (HGNC Symbol)

Synonyms

 CREB-H

Description

 CAMP responsive element binding protein 3-like 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 4153601 - 4173054

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000060566 (version 83.38)

Entrez gene

 84699

UniProt

 Q68CJ9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q68CJ9

Antibodypedia

 CREB3L3 antibodies

PROTEIN BROWSER
CREB3L3-001
CREB3L3-002
CREB3L3-003
CREB3L3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CREB3L3-001
ENSP00000078445
ENST00000078445
Q68CJ9 [Direct mapping]
Cyclic AMP-responsive element-binding protein 3-like protein 3 Processed cyclic AMP-responsive element-binding protein 3-like protein 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0035497 [cAMP response element binding]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Show all
 461 aa
49.1 kDa 		No 1
CREB3L3-002
ENSP00000472399
ENST00000602257
Q68CJ9 [Direct mapping]
Cyclic AMP-responsive element-binding protein 3-like protein 3 Processed cyclic AMP-responsive element-binding protein 3-like protein 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Basic domains
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0035497 [cAMP response element binding]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Show all
 459 aa
48.8 kDa 		No 1
CREB3L3-003
ENSP00000470119
ENST00000602147
Q68CJ9 [Direct mapping]
Cyclic AMP-responsive element-binding protein 3-like protein 3 Processed cyclic AMP-responsive element-binding protein 3-like protein 3
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0035497 [cAMP response element binding]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Show all
 337 aa
35.8 kDa 		No 0
CREB3L3-005
ENSP00000469355
ENST00000595923
Q68CJ9 [Direct mapping]
Cyclic AMP-responsive element-binding protein 3-like protein 3 Processed cyclic AMP-responsive element-binding protein 3-like protein 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Basic domains
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0035497 [cAMP response element binding]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
Show all
 460 aa
48.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.