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BCAT1

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GENERAL INFORMATION

Gene name

 BCAT1

Gene description

 Branched chain amino-acid transaminase 1, cytosolic

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (RH-30, NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RH-30, NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 BCAT1 (HGNC Symbol)

Synonyms

 BCT1

Description

 Branched chain amino-acid transaminase 1, cytosolic (HGNC Symbol)

Entrez gene summary

 This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]

Chromosome

 12

Cytoband

 p12.1

Chromosome location (bp)

 24810022 - 24949459

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000060982 (version 83.38)

Entrez gene

 586

UniProt

 P54687 (UniProt - Evidence at protein level)

neXtProt

 NX_P54687

Antibodypedia

 BCAT1 antibodies

PROTEIN BROWSER
BCAT1-001
BCAT1-002
BCAT1-003
BCAT1-004
BCAT1-006
BCAT1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCAT1-001
ENSP00000261192
ENST00000261192
P54687 [Direct mapping]
Branched-chain-amino-acid aminotransferase, cytosolic
A0A024RAV0 [Target identity:100%; Query identity:100%]
Branched-chain-amino-acid aminotransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 386 aa
43 kDa 		No 0
BCAT1-002
ENSP00000339805
ENST00000342945
P54687 [Direct mapping]
Branched-chain-amino-acid aminotransferase, cytosolic
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 325 aa
36.3 kDa 		No 0
BCAT1-003
ENSP00000440827
ENST00000539780
P54687 [Direct mapping]
Branched-chain-amino-acid aminotransferase, cytosolic
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 349 aa
38.6 kDa 		No 0
BCAT1-004
ENSP00000443459
ENST00000539282
P54687 [Direct mapping]
Branched-chain-amino-acid aminotransferase, cytosolic
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 398 aa
44.1 kDa 		No 0
BCAT1-006
ENSP00000440817
ENST00000538118
P54687 [Direct mapping]
Branched-chain-amino-acid aminotransferase, cytosolic
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 385 aa
42.8 kDa 		No 0
BCAT1-008
ENSP00000438593
ENST00000546285
F5H2F2 [Direct mapping]
Branched-chain-amino-acid aminotransferase, cytosolic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 144 aa
16.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.