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HDAC7

GENERAL INFORMATION

Gene name

 HDAC7

Gene description

 Histone deacetylase 7

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 17
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HDAC7 (HGNC Symbol)

Synonyms

 DKFZP586J0917, HDAC7A

Description

 Histone deacetylase 7 (HGNC Symbol)

Entrez gene summary

 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.11

Chromosome location (bp)

 47782722 - 47833132

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000061273 (version 83.38)

Entrez gene

 51564

UniProt

 Q8WUI4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WUI4

Antibodypedia

 HDAC7 antibodies

PROTEIN BROWSER
«
HDAC7-001
HDAC7-002
HDAC7-009
HDAC7-010
HDAC7-011
HDAC7-012
HDAC7-013
HDAC7-014
HDAC7-015
HDAC7-016
HDAC7-018
HDAC7-019
HDAC7-020
HDAC7-021
HDAC7-028
HDAC7-029
HDAC7-031
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HDAC7-001
ENSP00000080059
ENST00000080059
Q8WUI4 [Direct mapping]
Histone deacetylase 7
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001570 [vasculogenesis]
GO:0003682 [chromatin binding]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007043 [cell-cell junction assembly]
GO:0007219 [Notch signaling pathway]
GO:0016568 [chromatin modification]
GO:0016925 [protein sumoylation]
GO:0019901 [protein kinase binding]
GO:0030182 [neuron differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0033613 [activating transcription factor binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0046872 [metal ion binding]
GO:0051402 [neuron apoptotic process]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071889 [14-3-3 protein binding]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:1901215 [negative regulation of neuron death]
GO:1901223 [negative regulation of NIK/NF-kappaB signaling]
Show all
 991 aa
106.7 kDa 		No 0
HDAC7-002
ENSP00000351326
ENST00000354334
Q8WUI4 [Direct mapping]
Histone deacetylase 7
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007219 [Notch signaling pathway]
GO:0016568 [chromatin modification]
GO:0016925 [protein sumoylation]
GO:0019901 [protein kinase binding]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0033613 [activating transcription factor binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0046872 [metal ion binding]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0071889 [14-3-3 protein binding]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:1901223 [negative regulation of NIK/NF-kappaB signaling]
Show all
 954 aa
102.9 kDa 		No 0
HDAC7-009
ENSP00000387792
ENST00000417107
C9JZ79 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 78 aa
9.1 kDa 		No 0
HDAC7-010
ENSP00000397236
ENST00000450805
C9JBC2 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 113 aa
12.8 kDa 		No 0
HDAC7-011
ENSP00000403149
ENST00000433685
C9JGF5 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 88 aa
10.1 kDa 		No 0
HDAC7-012
ENSP00000389501
ENST00000447463
C9JNI4 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 153 aa
17.2 kDa 		No 0
HDAC7-013
ENSP00000404394
ENST00000427332
Q8WUI4 [Direct mapping]
Histone deacetylase 7
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007219 [Notch signaling pathway]
GO:0016568 [chromatin modification]
GO:0016925 [protein sumoylation]
GO:0019901 [protein kinase binding]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0033613 [activating transcription factor binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0046872 [metal ion binding]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0071889 [14-3-3 protein binding]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:1901223 [negative regulation of NIK/NF-kappaB signaling]
Show all
 952 aa
102.9 kDa 		No 0
HDAC7-014
ENSP00000388561
ENST00000434070
C9JNI4 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 153 aa
17.2 kDa 		No 0
HDAC7-015
ENSP00000390415
ENST00000445237
C9JH46 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 51 aa
5.9 kDa 		No 0
HDAC7-016
ENSP00000412155
ENST00000421231
C9J102 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 138 aa
15.5 kDa 		No 0
HDAC7-018
ENSP00000400811
ENST00000417902
C9JVZ1 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 133 aa
14.7 kDa 		No 0
HDAC7-019
ENSP00000396159
ENST00000430670
C9JEB6 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 274 aa
29.8 kDa 		No 0
HDAC7-020
ENSP00000411058
ENST00000440293
C9JAH2 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 160 aa
17.9 kDa 		No 0
HDAC7-021
ENSP00000410068
ENST00000422254
C9JF80 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 141 aa
16.1 kDa 		No 0
HDAC7-028
ENSP00000448532
ENST00000552960
Q8WUI4 [Direct mapping]
Histone deacetylase 7
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007219 [Notch signaling pathway]
GO:0016568 [chromatin modification]
GO:0016925 [protein sumoylation]
GO:0019901 [protein kinase binding]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0033613 [activating transcription factor binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0046872 [metal ion binding]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0071889 [14-3-3 protein binding]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:1901223 [negative regulation of NIK/NF-kappaB signaling]
Show all
 974 aa
105.1 kDa 		No 0
HDAC7-029
ENSP00000369984
ENST00000380610
J3KPH8 [Direct mapping]
Histone deacetylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0004407 [histone deacetylase activity]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016568 [chromatin modification]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0046872 [metal ion binding]
GO:0070932 [histone H3 deacetylation]
Show all
 1014 aa
109 kDa 		No 0
HDAC7-031
ENSP00000446538
ENST00000548080
H0YH91 [Direct mapping]
Histone deacetylase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 384 aa
41.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.