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CDH3

CANCER ATLAS

Gene description

 Cadherin 3, type 1, P-cadherin (placental)

Protein class

 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA001767
CAB002487

GENE INFORMATION

Gene name

 CDH3 (HGNC Symbol)

Synonyms

 CDHP, PCAD

Description

 Cadherin 3, type 1, P-cadherin (placental) (HGNC Symbol)

Entrez gene summary

 This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 68636189 - 68722616

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000062038 (version 83.38)

Entrez gene

 1001

UniProt

 P22223 (UniProt - Evidence at protein level)

neXtProt

 NX_P22223

Antibodypedia

 CDH3 antibodies

PROTEIN BROWSER
CDH3-001
CDH3-002
CDH3-005
CDH3-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDH3-001
ENSP00000264012
ENST00000264012
P22223 [Direct mapping]
Cadherin-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0003674 [molecular_function]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007601 [visual perception]
GO:0010628 [positive regulation of gene expression]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0022405 [hair cycle process]
GO:0031424 [keratinization]
GO:0032773 [positive regulation of monophenol monooxygenase activity]
GO:0032912 [negative regulation of transforming growth factor beta2 production]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042060 [wound healing]
GO:0042493 [response to drug]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0045216 [cell-cell junction organization]
GO:0048023 [positive regulation of melanin biosynthetic process]
GO:0051796 [negative regulation of catagen]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060901 [regulation of hair cycle by canonical Wnt signaling pathway]
GO:1902910 [positive regulation of melanosome transport]
Show all
 829 aa
91.4 kDa 		Yes 1
CDH3-002
ENSP00000398485
ENST00000429102
P22223 [Direct mapping]
Cadherin-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0003674 [molecular_function]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007601 [visual perception]
GO:0010628 [positive regulation of gene expression]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022405 [hair cycle process]
GO:0031424 [keratinization]
GO:0032773 [positive regulation of monophenol monooxygenase activity]
GO:0032912 [negative regulation of transforming growth factor beta2 production]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0045216 [cell-cell junction organization]
GO:0048023 [positive regulation of melanin biosynthetic process]
GO:0051796 [negative regulation of catagen]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060901 [regulation of hair cycle by canonical Wnt signaling pathway]
GO:1902910 [positive regulation of melanosome transport]
Show all
 784 aa
86.6 kDa 		Yes 1
CDH3-005
ENSP00000463364
ENST00000568292
J3QL41 [Direct mapping]
Cadherin-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 155 aa
17.3 kDa 		No 1
CDH3-010
ENSP00000463415
ENST00000569080
J3QL75 [Direct mapping]
Cadherin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 81 aa
9.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.