Fields »
ABOUT
HELP
BLOG
GPBP1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 GPBP1

Gene description

 GC-rich promoter binding protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol & vesicles. In addition localized to the plasma membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved), Cytosol (supported)

Additional location

 In addition localized to the Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA037773
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol & vesicles. In addition localized to the plasma membrane.

Main location

 Vesicles (approved), Cytosol (supported)

Additional location

 Plasma membrane (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA037773 A-431 Vesicles
Plasma membrane
Cytosol
HPA037773 U-2 OS Vesicles
Cytosol
HPA037773 U-251 MG Vesicles
Cytosol

GENE INFORMATION

Gene name

 GPBP1 (HGNC Symbol)

Synonyms

 DKFZp761C169, vasculin

Description

 GC-rich promoter binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 5

Cytoband

 q11.2

Chromosome location (bp)

 57173948 - 57264679

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000062194 (version 83.38)

Entrez gene

 65056

UniProt

 Q86WP2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86WP2

Antibodypedia

 GPBP1 antibodies

PROTEIN BROWSER
GPBP1-001
GPBP1-002
GPBP1-003
GPBP1-005
GPBP1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPBP1-001
ENSP00000401596
ENST00000424459
D4PHA4 [Direct mapping]
GC-rich promoter binding protein 1, isoform CRA_c; Vasculin
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 493 aa
55.5 kDa 		No 0
GPBP1-002
ENSP00000264779
ENST00000264779
Q86WP2 [Direct mapping]
Vasculin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 480 aa
54.1 kDa 		No 0
GPBP1-003
ENSP00000421202
ENST00000506184
Q86WP2 [Direct mapping]
Vasculin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 473 aa
53.3 kDa 		No 0
GPBP1-005
ENSP00000421709
ENST00000514387
Q86WP2 [Direct mapping]
Vasculin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 302 aa
33.8 kDa 		No 0
GPBP1-006
ENSP00000422337
ENST00000511209
Q86WP2 [Direct mapping]
Vasculin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 465 aa
52.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.