Cell atlas - LTK - The Human Protein Atlas

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LTK

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	LTK
Gene description	Leukocyte receptor tyrosine kinase
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (THP-1, NB-4, RH-30, HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA059545
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (THP-1, NB-4, RH-30, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059545	RH-30	Vesicles
	HPA059545	SH-SY5Y	Vesicles
	HPA059545	U-2 OS	Vesicles

GENE INFORMATION
Gene name	LTK (HGNC Symbol)
Synonyms	TYK1
Description	Leukocyte receptor tyrosine kinase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	41503638 - 41513887
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000062524 (version 83.38)
Entrez gene	4058
UniProt	P29376 (UniProt - Evidence at protein level)
neXtProt	NX_P29376
Antibodypedia	LTK antibodies

PROTEIN BROWSER

LTK-001	LTK-002	LTK-004	LTK-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LTK-001 ENSP00000263800 ENST00000263800	P29376 [Direct mapping] Leukocyte tyrosine kinase receptor Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008283 [cell proliferation] GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] GO:0010976 [positive regulation of neuron projection development] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0043066 [negative regulation of apoptotic process] GO:0071300 [cellular response to retinoic acid] Show all	864 aa 91.7 kDa	Yes	1
LTK-002 ENSP00000347293 ENST00000355166	P29376 [Direct mapping] Leukocyte tyrosine kinase receptor Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008283 [cell proliferation] GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] GO:0010976 [positive regulation of neuron projection development] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0043066 [negative regulation of apoptotic process] GO:0071300 [cellular response to retinoic acid] Show all	803 aa 86.2 kDa	Yes	1
LTK-004 ENSP00000392196 ENST00000453182	P29376 [Direct mapping] Leukocyte tyrosine kinase receptor Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008283 [cell proliferation] GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] GO:0010976 [positive regulation of neuron projection development] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0043066 [negative regulation of apoptotic process] GO:0071300 [cellular response to retinoic acid] Show all	734 aa 78.7 kDa	Yes	0
LTK-005 ENSP00000458111 ENST00000561619	H3BVG6 [Direct mapping] Tyrosine-protein kinase receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	562 aa 62.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.