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APPBP2

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GENERAL INFORMATION

Gene name

 APPBP2

Gene description

 Amyloid beta precursor protein (cytoplasmic tail) binding protein 2

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA050874
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA050874 MCF7 No staining    
HPA050874 RH-30 Cytosol
HPA050874 U-2 OS No staining    

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000018481 (version 83)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location
HPA050874 NIH 3T3 No staining

GENE INFORMATION

Gene name

 APPBP2 (HGNC Symbol)

Synonyms

 Hs.84084, KIAA0228, PAT1

Description

 Amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 17

Cytoband

 q23.2

Chromosome location (bp)

 60443149 - 60526219

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000062725 (version 83.38)

Entrez gene

 10513

UniProt

 Q92624 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92624

Antibodypedia

 APPBP2 antibodies

PROTEIN BROWSER
APPBP2-001
APPBP2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APPBP2-001
ENSP00000083182
ENST00000083182
Q92624 [Direct mapping]
Amyloid protein-binding protein 2
A0A024QZ47 [Target identity:100%; Query identity:100%]
Amyloid beta protein (Cytoplasmic tail) binding protein 2, isoform CRA_a
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
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GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0006886 [intracellular protein transport]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0046907 [intracellular transport]
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 585 aa
66.9 kDa 		No 0
APPBP2-003
ENSP00000464962
ENST00000585368
K7EIZ9 [Direct mapping]
Amyloid protein-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
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 123 aa
14.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.