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Malignant cells showed moderate to strong nuclear staining. Several malignant gliomas and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
GSC2 (HGNC Symbol)
Synonyms
GSCL
Description
Goosecoid homeobox 2 (HGNC Symbol)
Entrez gene summary
Goosecoidlike (GSCL), a homeodomain-containing gene, resides in the critical region for VCFS/DGS on 22q11. Velocardiofacial syndrome (VCFS) is a developmental disorder characterized by conotruncal heart defects, craniofacial anomalies, and learning disabilities. VCFS is phenotypically related to DiGeorge syndrome (DGS) and both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology. The gene is expressed in a limited number of adult tissues, as well as in early human development. [provided by RefSeq, Jul 2008]
