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GPC1

GENERAL INFORMATION

Gene name

 GPC1

Gene description

 Glypican 1

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous positivity in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA030571
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GPC1 (HGNC Symbol)

Synonyms

 glypican

Description

 Glypican 1 (HGNC Symbol)

Entrez gene summary

 Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 240435671 - 240468078

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000063660 (version 83.38)

Entrez gene

 2817

UniProt

 P35052 (UniProt - Evidence at protein level)

neXtProt

 NX_P35052

Antibodypedia

 GPC1 antibodies

PROTEIN BROWSER
GPC1-001
GPC1-002
GPC1-007
GPC1-008
GPC1-009
GPC1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPC1-001
ENSP00000264039
ENST00000264039
P35052 [Direct mapping]
Glypican-1 Secreted glypican-1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005507 [copper ion binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005768 [endosome]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0007411 [axon guidance]
GO:0007603 [phototransduction, visible light]
GO:0014037 [Schwann cell differentiation]
GO:0016020 [membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0030200 [heparan sulfate proteoglycan catabolic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0031225 [anchored component of membrane]
GO:0032288 [myelin assembly]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0043202 [lysosomal lumen]
GO:0043236 [laminin binding]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0070062 [extracellular exosome]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
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 558 aa
61.7 kDa 		Yes 1
GPC1-002
ENSP00000415077
ENST00000420138
H7C410 [Direct mapping]
Glypican-1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005578 [proteinaceous extracellular matrix]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0031225 [anchored component of membrane]
GO:0043395 [heparan sulfate proteoglycan binding]
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 486 aa
54 kDa 		No 1
GPC1-007
ENSP00000410251
ENST00000426280
C9J4Y6 [Direct mapping]
Glypican-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005578 [proteinaceous extracellular matrix]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0031225 [anchored component of membrane]
GO:0043395 [heparan sulfate proteoglycan binding]
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 156 aa
18.1 kDa 		No 0
GPC1-008
ENSP00000389276
ENST00000427506
H7BZE9 [Direct mapping]
Glypican-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005578 [proteinaceous extracellular matrix]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0031225 [anchored component of membrane]
GO:0043395 [heparan sulfate proteoglycan binding]
Show all
 162 aa
18.6 kDa 		No 0
GPC1-009
ENSP00000392629
ENST00000425056
H7C024 [Direct mapping]
Glypican-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005578 [proteinaceous extracellular matrix]
GO:0016020 [membrane]
GO:0043395 [heparan sulfate proteoglycan binding]
Show all
 294 aa
32.9 kDa 		No 0
GPC1-010
ENSP00000390242
ENST00000455111
H7BZL4 [Direct mapping]
Glypican-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005578 [proteinaceous extracellular matrix]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0031225 [anchored component of membrane]
GO:0043395 [heparan sulfate proteoglycan binding]
Show all
 281 aa
30.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.