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Most of the malignant cells displayed moderate to strong nuclear and/or cytoplasmic immunoreactivity. A few cases of lung and ovarian cancers as well as malignant gliomas and lymphomas were either negative or weakly stained.
GENE INFORMATION
Gene name
TSPAN32 (HGNC Symbol)
Synonyms
PHEMX, TSSC6
Description
Tetraspanin 32 (HGNC Symbol)
Entrez gene summary
This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
