Expression of LPAR2 in cancer - Summary

CANCER ATLAS

Gene description

Lysophosphatidic acid receptor 2

Protein class

G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA019616

GENE INFORMATION
Gene name	LPAR2 (HGNC Symbol)
Synonyms	EDG-4, EDG4, LPA2
Description	Lysophosphatidic acid receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	19623668 - 19628930
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000064547 (version 83.38)
Entrez gene	9170
UniProt	Q9HBW0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HBW0
Antibodypedia	LPAR2 antibodies

PROTEIN BROWSER

LPAR2-001	LPAR2-002	LPAR2-003	LPAR2-004	LPAR2-006	LPAR2-008	LPAR2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LPAR2-001 ENSP00000465280 ENST00000586703	Q9HBW0 [Direct mapping] Lysophosphatidic acid receptor 2 A0A024R7M9 [Target identity:100%; Query identity:100%] Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4, isoform CRA_a Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008289 [lipid binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0030139 [endocytic vesicle] GO:0070915 [lysophosphatidic acid receptor activity] Show all	351 aa 39.1 kDa	No	7
LPAR2-002 ENSP00000384665 ENST00000407877	Q9HBW0 [Direct mapping] Lysophosphatidic acid receptor 2 A0A024R7M9 [Target identity:100%; Query identity:100%] Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4, isoform CRA_a Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008289 [lipid binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0030139 [endocytic vesicle] GO:0070915 [lysophosphatidic acid receptor activity] Show all	351 aa 39.1 kDa	No	7
LPAR2-003 ENSP00000443256 ENST00000542587	Q9HBW0 [Direct mapping] Lysophosphatidic acid receptor 2 A0A024R7M9 [Target identity:100%; Query identity:100%] Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4, isoform CRA_a Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008289 [lipid binding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0030139 [endocytic vesicle] GO:0030165 [PDZ domain binding] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0043410 [positive regulation of MAPK cascade] GO:0070915 [lysophosphatidic acid receptor activity] Show all	351 aa 39.1 kDa	No	7
LPAR2-004 ENSP00000466112 ENST00000588233	K7ELJ6 [Direct mapping] Lysophosphatidic acid receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	75 aa 8.4 kDa	No	1
LPAR2-006 ENSP00000466940 ENST00000588461	K7ENG7 [Direct mapping] Lysophosphatidic acid receptor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		20 aa 2.4 kDa	No	0
LPAR2-008 ENSP00000468132 ENST00000591042	K7ER68 [Direct mapping] Lysophosphatidic acid receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	80 aa 8.9 kDa	No	1
LPAR2-009 ENSP00000465206 ENST00000592061	K7EJJ9 [Direct mapping] Lysophosphatidic acid receptor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.9 kDa	No	0