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CNN2

CANCER ATLAS

Gene description

 Calponin 2

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA049095

GENE INFORMATION

Gene name

 CNN2

Synonyms

Description

 Calponin 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 1026581 - 1039068

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000064666 (version 83.38)

Entrez gene

 1265

UniProt

 Q99439 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99439

Antibodypedia

 CNN2 antibodies

PROTEIN BROWSER
CNN2-001
CNN2-003
CNN2-004
CNN2-005
CNN2-006
CNN2-007
CNN2-008
CNN2-009
CNN2-010
CNN2-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNN2-001
ENSP00000263097
ENST00000263097
Q99439 [Direct mapping]
Calponin-2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005856 [cytoskeleton]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007010 [cytoskeleton organization]
GO:0016020 [membrane]
GO:0031032 [actomyosin structure organization]
GO:0032970 [regulation of actin filament-based process]
GO:0070062 [extracellular exosome]
GO:0071260 [cellular response to mechanical stimulus]
Show all
 309 aa
33.7 kDa 		No 0
CNN2-003
ENSP00000340129
ENST00000348419
Q99439 [Direct mapping]
Calponin-2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005856 [cytoskeleton]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007010 [cytoskeleton organization]
GO:0016020 [membrane]
GO:0031032 [actomyosin structure organization]
GO:0032970 [regulation of actin filament-based process]
GO:0070062 [extracellular exosome]
GO:0071260 [cellular response to mechanical stimulus]
Show all
 270 aa
29.5 kDa 		No 0
CNN2-004
ENSP00000457968
ENST00000565096
B4DDF4 [Direct mapping]
Calponin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005856 [cytoskeleton]
GO:0031032 [actomyosin structure organization]
Show all
 298 aa
32.6 kDa 		No 0
CNN2-005
ENSP00000456436
ENST00000562958
B4DUT8 [Direct mapping]
Calponin
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005856 [cytoskeleton]
GO:0010628 [positive regulation of gene expression]
GO:0030097 [hemopoiesis]
GO:0030336 [negative regulation of cell migration]
GO:0031032 [actomyosin structure organization]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0050765 [negative regulation of phagocytosis]
Show all
 330 aa
35.9 kDa 		No 0
CNN2-006
ENSP00000455777
ENST00000562075
H3BQH0 [Direct mapping]
Calponin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
Show all
 154 aa
16.7 kDa 		No 0
CNN2-007
ENSP00000479188
ENST00000562015
A0A087WV51 [Direct mapping]
Calponin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
Show all
 66 aa
7.4 kDa 		No 0
CNN2-008
ENSP00000484533
ENST00000566695
A0A087X1X5 [Direct mapping]
Calponin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005856 [cytoskeleton]
GO:0031032 [actomyosin structure organization]
Show all
 191 aa
21 kDa 		No 0
CNN2-009
ENSP00000458137
ENST00000568865
H3BVI6 [Direct mapping]
Calponin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005856 [cytoskeleton]
GO:0031032 [actomyosin structure organization]
Show all
 218 aa
23.9 kDa 		No 0
CNN2-010
ENSP00000475175
ENST00000607102
U3KPS3 [Direct mapping]
Calponin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0031032 [actomyosin structure organization]
Show all
 103 aa
10.9 kDa 		No 0
CNN2-014
ENSP00000484749
ENST00000606983
A0A087X271 [Direct mapping]
Calponin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005856 [cytoskeleton]
GO:0031032 [actomyosin structure organization]
Show all
 179 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.