Tissue expression of SNCAIP - Summary - The Human Protein Atlas

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SNCAIP

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SNCAIP
Gene description	Synuclein, alpha interacting protein
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (ovary, endometrium)
GTEx:	Tissue enhanced (ovary)
FANTOM5:	Tissue enhanced (endometrium)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA064687
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (ovary, endometrium)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (ovary)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (endometrium)

GENE INFORMATION
Gene name	SNCAIP (HGNC Symbol)
Synonyms	SYPH1
Description	Synuclein, alpha interacting protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	5
Cytoband	q23.2
Chromosome location (bp)	122311354 - 122464219
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000064692 (version 83.38)
Entrez gene	9627
UniProt	Q9Y6H5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6H5
Antibodypedia	SNCAIP antibodies

PROTEIN BROWSER

SNCAIP-001	SNCAIP-002	SNCAIP-010	SNCAIP-015	SNCAIP-016	SNCAIP-017	SNCAIP-018	SNCAIP-019	SNCAIP-201	SNCAIP-202	SNCAIP-203	SNCAIP-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SNCAIP-001 ENSP00000261368 ENST00000261368	Q9Y6H5 [Direct mapping] Synphilin-1 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008021 [synaptic vesicle] GO:0008219 [cell death] GO:0031625 [ubiquitin protein ligase binding] GO:0042417 [dopamine metabolic process] GO:0042734 [presynaptic membrane] GO:0042802 [identical protein binding] GO:0043025 [neuronal cell body] GO:0046928 [regulation of neurotransmitter secretion] GO:0090083 [regulation of inclusion body assembly] Show all	919 aa 100.4 kDa	No	0
SNCAIP-002 ENSP00000261367 ENST00000261367	Q9Y6H5 [Direct mapping] Synphilin-1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008021 [synaptic vesicle] GO:0008219 [cell death] GO:0031625 [ubiquitin protein ligase binding] GO:0042417 [dopamine metabolic process] GO:0042734 [presynaptic membrane] GO:0042802 [identical protein binding] GO:0043025 [neuronal cell body] GO:0046928 [regulation of neurotransmitter secretion] GO:0090083 [regulation of inclusion body assembly] Show all	1016 aa 111.5 kDa	No	0
SNCAIP-010 ENSP00000422106 ENST00000509154	D6R9G8 [Direct mapping] Synphilin-1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	858 aa 93.9 kDa	No	0
SNCAIP-015 ENSP00000427587 ENST00000509652	D6RHX3 [Direct mapping] Synphilin-1 Show all	Predicted intracellular proteins Show all		14 aa 1.7 kDa	No	0
SNCAIP-016 ENSP00000426551 ENST00000506272	D6RFL3 [Direct mapping] Synphilin-1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all		161 aa 18 kDa	No	0
SNCAIP-017 ENSP00000422610 ENST00000508681	D6RBR2 [Direct mapping] Synphilin-1 Show all	Predicted intracellular proteins Show all		98 aa 11.1 kDa	No	0
SNCAIP-018 ENSP00000425063 ENST00000514497	D6REC1 [Direct mapping] Synphilin-1 Show all	Predicted intracellular proteins Show all		68 aa 7.6 kDa	No	0
SNCAIP-019 ENSP00000427090 ENST00000514467	D6RD29 [Direct mapping] Synphilin-1 Show all	Predicted intracellular proteins Show all		135 aa 14.8 kDa	No	0
SNCAIP-201 ENSP00000368854 ENST00000379538	Q9Y6H5 [Direct mapping] Synphilin-1 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008021 [synaptic vesicle] GO:0008219 [cell death] GO:0031625 [ubiquitin protein ligase binding] GO:0042417 [dopamine metabolic process] GO:0042734 [presynaptic membrane] GO:0042802 [identical protein binding] GO:0043025 [neuronal cell body] GO:0046928 [regulation of neurotransmitter secretion] GO:0090083 [regulation of inclusion body assembly] Show all	603 aa 66.6 kDa	No	0
SNCAIP-202 ENSP00000394392 ENST00000414317	Q6L980 [Direct mapping] Synphilin-1; Synphilin-1g protein Show all	Predicted intracellular proteins Show all		62 aa 6.9 kDa	No	0
SNCAIP-203 ENSP00000426904 ENST00000504884	Q6L981 [Direct mapping] Synphilin-1; Synphilin-1f protein Show all	Predicted intracellular proteins Show all		88 aa 10.2 kDa	No	0
SNCAIP-204 ENSP00000441681 ENST00000542191	Q6L983 [Direct mapping] Synphilin-1; Synphilin-1d protein Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all		113 aa 12.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.