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POU1F1

GENERAL INFORMATION

Gene name

 POU1F1

Gene description

 POU class 1 homeobox 1

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Tissue enriched (pituitary gland)
FANTOM5:Tissue enriched (pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in the anterior pituitary gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with external characterization data and GTEx RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041646 , HPA050624
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Pituitary gland

Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION

Gene name

 POU1F1 (HGNC Symbol)

Synonyms

 GHF-1, PIT1, POU1F1a

Description

 POU class 1 homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p11.2

Chromosome location (bp)

 87259404 - 87276587

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000064835 (version 83.38)

Entrez gene

 5449

UniProt

 P28069 (UniProt - Evidence at protein level)

neXtProt

 NX_P28069

Antibodypedia

 POU1F1 antibodies

PROTEIN BROWSER
POU1F1-001
POU1F1-002
POU1F1-003
POU1F1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POU1F1-001
ENSP00000263781
ENST00000350375
P28069 [Direct mapping]
Pituitary-specific positive transcription factor 1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008285 [negative regulation of cell proliferation]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 291 aa
32.9 kDa 		No 0
POU1F1-002
ENSP00000342931
ENST00000344265
P28069 [Direct mapping]
Pituitary-specific positive transcription factor 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0001708 [cell fate specification]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0021983 [pituitary gland development]
GO:0021984 [adenohypophysis development]
GO:0030183 [B cell differentiation]
GO:0032962 [positive regulation of inositol trisphosphate biosynthetic process]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0043565 [sequence-specific DNA binding]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051169 [nuclear transport]
GO:0060126 [somatotropin secreting cell differentiation]
GO:0060133 [somatotropin secreting cell development]
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 317 aa
35.7 kDa 		No 0
POU1F1-003
ENSP00000452610
ENST00000560656
H0YK06 [Direct mapping]
Pituitary-specific positive transcription factor 1
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Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
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 169 aa
18.9 kDa 		No 0
POU1F1-004
ENSP00000454072
ENST00000561167
H0YNM5 [Direct mapping]
POU domain protein
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
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 216 aa
24.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.