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IPO5

CANCER ATLAS

Gene description

 Importin 5

Protein class

 Plasma proteins, Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040983
HPA056548
CAB009110

GENE INFORMATION

Gene name

 IPO5 (HGNC Symbol)

Synonyms

 IMB3, KPNB3, MGC2068, Pse1, RANBP5

Description

 Importin 5 (HGNC Symbol)

Entrez gene summary

 Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q32.2

Chromosome location (bp)

 97953658 - 98024297

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065150 (version 83.38)

Entrez gene

 3843

UniProt

 O00410 (UniProt - Evidence at protein level)

neXtProt

 NX_O00410

Antibodypedia

 IPO5 antibodies

PROTEIN BROWSER
«
IPO5-001
IPO5-002
IPO5-003
IPO5-004
IPO5-006
IPO5-008
IPO5-009
IPO5-010
IPO5-011
IPO5-012
IPO5-014
IPO5-015
IPO5-016
IPO5-017
IPO5-019
IPO5-020
IPO5-021
IPO5-022
IPO5-023
IPO5-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IPO5-001
ENSP00000261574
ENST00000261574
O00410 [Direct mapping]
Importin-5
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000060 [protein import into nucleus, translocation]
GO:0005095 [GTPase inhibitor activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006610 [ribosomal protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0008139 [nuclear localization sequence binding]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0031965 [nuclear membrane]
GO:0034260 [negative regulation of GTPase activity]
GO:0034399 [nuclear periphery]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0071230 [cellular response to amino acid stimulus]
Show all
 1115 aa
125.5 kDa 		No 0
IPO5-002
ENSP00000350219
ENST00000357602
O00410 [Direct mapping]
Importin-5
A0A024RDY0 [Target identity:100%; Query identity:100%]
RAN binding protein 5, isoform CRA_d
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000060 [protein import into nucleus, translocation]
GO:0005095 [GTPase inhibitor activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006610 [ribosomal protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0008139 [nuclear localization sequence binding]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0031965 [nuclear membrane]
GO:0034260 [negative regulation of GTPase activity]
GO:0034399 [nuclear periphery]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0071230 [cellular response to amino acid stimulus]
Show all
 1097 aa
123.6 kDa 		No 0
IPO5-003
ENSP00000385938
ENST00000403772
H0Y3V4 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 182 aa
20.5 kDa 		No 0
IPO5-004
ENSP00000419764
ENST00000469360
H0Y8C6 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 1099 aa
123.7 kDa 		No 0
IPO5-006
ENSP00000418393
ENST00000490680
O00410 [Direct mapping]
Importin-5
A0A024RDY0 [Target identity:100%; Query identity:100%]
RAN binding protein 5, isoform CRA_d
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000060 [protein import into nucleus, translocation]
GO:0005095 [GTPase inhibitor activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006610 [ribosomal protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0008139 [nuclear localization sequence binding]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0031965 [nuclear membrane]
GO:0034260 [negative regulation of GTPase activity]
GO:0034399 [nuclear periphery]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0071230 [cellular response to amino acid stimulus]
Show all
 1097 aa
123.6 kDa 		No 0
IPO5-008
ENSP00000420284
ENST00000460070
E7EV12 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 142 aa
15.7 kDa 		No 0
IPO5-009
ENSP00000417993
ENST00000489058
C9J583 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 50 aa
5.4 kDa 		No 0
IPO5-010
ENSP00000417721
ENST00000485433
C9J875 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 75 aa
8.2 kDa 		No 0
IPO5-011
ENSP00000420043
ENST00000481689
E7ETV8 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 129 aa
14.5 kDa 		No 0
IPO5-012
ENSP00000419860
ENST00000480611
E7EWK4 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 117 aa
12.9 kDa 		No 0
IPO5-014
ENSP00000419766
ENST00000481455
E7EX05 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 119 aa
13.1 kDa 		No 0
IPO5-015
ENSP00000420149
ENST00000463157
C9JQT6 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 88 aa
9.7 kDa 		No 0
IPO5-016
ENSP00000419166
ENST00000493281
C9JXE0 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 64 aa
7 kDa 		No 0
IPO5-017
ENSP00000419797
ENST00000471898
C9JZD8 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 74 aa
8.2 kDa 		No 0
IPO5-019
ENSP00000417162
ENST00000496368
E7ESA1 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 98 aa
10.8 kDa 		No 0
IPO5-020
ENSP00000408885
ENST00000421861
E7ESZ1 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 106 aa
11.6 kDa 		No 0
IPO5-021
ENSP00000420079
ENST00000475420
E7ETV3 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 170 aa
19.1 kDa 		No 0
IPO5-022
ENSP00000419003
ENST00000480641
C9JZ53 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 77 aa
8.7 kDa 		No 0
IPO5-023
ENSP00000420491
ENST00000473582
C9JMV5 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
Show all
 165 aa
18.9 kDa 		No 0
IPO5-201
ENSP00000487097
ENST00000631030
F8WF30 [Direct mapping]
Importin-5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 63 aa
7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.