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Ovarian, pancreatic cancers along with a majority cases of melanomas, cervical, endometrial, liver, lung, skin, stomach, testicular and urothelial cancers displayed moderate membranous positivity. Colorectal cancers showed strong immunoreactivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
TRAM2 (HGNC Symbol)
Synonyms
KIAA0057
Description
Translocation associated membrane protein 2 (HGNC Symbol)
Entrez gene summary
TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]