Cell atlas - DGKA - The Human Protein Atlas

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DGKA

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm
	Vesicles

Human cell
	Mitochondria
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	DGKA
Gene description	Diacylglycerol kinase, alpha 80kDa
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the mitochondria & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Nucleoplasm (approved), Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA045462
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the mitochondria & nucleoplasm.

Main location

Vesicles (approved)

Additional location

Nucleoplasm (approved), Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA045462	BJ	Nucleoplasm
			Vesicles
			Mitochondria
	HPA045462	RT4	Vesicles
	HPA045462	U-2 OS	Vesicles

GENE INFORMATION
Gene name	DGKA (HGNC Symbol)
Synonyms	DAGK, DAGK1, DGK-alpha
Description	Diacylglycerol kinase, alpha 80kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.2
Chromosome location (bp)	55927319 - 55954027
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065357 (version 83.38)
Entrez gene	1606
UniProt	P23743 (UniProt - Evidence at protein level)
neXtProt	NX_P23743
Antibodypedia	DGKA antibodies

PROTEIN BROWSER

DGKA-001	DGKA-012	DGKA-014	DGKA-016	DGKA-018	DGKA-023	DGKA-027	DGKA-036	DGKA-041	DGKA-043	DGKA-046	DGKA-052	DGKA-054	DGKA-055	DGKA-056	DGKA-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DGKA-001 ENSP00000328405 ENST00000331886	P23743 [Direct mapping] Diacylglycerol kinase alpha A0A024RB23 [Target identity:100%; Query identity:100%] Diacylglycerol kinase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005543 [phospholipid binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0030168 [platelet activation] GO:0035556 [intracellular signal transduction] Show all	735 aa 82.6 kDa	No	0
DGKA-012 ENSP00000450359 ENST00000551156	P23743 [Direct mapping] Diacylglycerol kinase alpha A0A024RB23 [Target identity:100%; Query identity:100%] Diacylglycerol kinase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0030168 [platelet activation] GO:0035556 [intracellular signal transduction] Show all	735 aa 82.6 kDa	No	0
DGKA-014 ENSP00000446515 ENST00000546878	F8VNZ9 [Direct mapping] Diacylglycerol kinase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.7 kDa	No	0
DGKA-016 ENSP00000449178 ENST00000547015	F8VWX8 [Direct mapping] Diacylglycerol kinase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		21 aa 2.4 kDa	No	0
DGKA-018 ENSP00000450977 ENST00000549629	G3V312 [Direct mapping] Diacylglycerol kinase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 11 kDa	No	0
DGKA-023 ENSP00000447460 ENST00000551707	F8W1M3 [Direct mapping] Diacylglycerol kinase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	133 aa 15.2 kDa	No	0
DGKA-027 ENSP00000402307 ENST00000432422	C9JM35 [Direct mapping] Diacylglycerol kinase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		116 aa 13.2 kDa	No	0
DGKA-036 ENSP00000451518 ENST00000552903	H0YJH4 [Direct mapping] Diacylglycerol kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005524 [ATP binding] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	202 aa 22.8 kDa	No	0
DGKA-041 ENSP00000447050 ENST00000549368	F8W1H7 [Direct mapping] Diacylglycerol kinase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	147 aa 16.8 kDa	No	0
DGKA-043 ENSP00000451743 ENST00000555218	G3V4E1 [Direct mapping] Diacylglycerol kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0035556 [intracellular signal transduction] Show all	545 aa 61.4 kDa	No	0
DGKA-046 ENSP00000450608 ENST00000555025	G3V4I3 [Direct mapping] Diacylglycerol kinase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 5.1 kDa	No	0
DGKA-052 ENSP00000451814 ENST00000557080	G3V4I3 [Direct mapping] Diacylglycerol kinase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 5.1 kDa	No	0
DGKA-054 ENSP00000451266 ENST00000556001	F8W1M3 [Direct mapping] Diacylglycerol kinase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	133 aa 15.2 kDa	No	0
DGKA-055 ENSP00000450999 ENST00000553783	G3V327 [Direct mapping] Diacylglycerol kinase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 12.2 kDa	No	0
DGKA-056 ENSP00000452353 ENST00000555090	G3V4I3 [Direct mapping] Diacylglycerol kinase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 5.1 kDa	No	0
DGKA-201 ENSP00000377703 ENST00000394147	P23743 [Direct mapping] Diacylglycerol kinase alpha A0A024RB23 [Target identity:100%; Query identity:100%] Diacylglycerol kinase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004143 [diacylglycerol kinase activity] GO:0005509 [calcium ion binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0030168 [platelet activation] GO:0035556 [intracellular signal transduction] Show all	735 aa 82.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.