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NDUFB4

GENERAL INFORMATION

Gene name

 NDUFB4

Gene description

 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous granular cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA051739
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NDUFB4 (HGNC Symbol)

Synonyms

 B15

Description

 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009]

Chromosome

 3

Cytoband

 q13.33

Chromosome location (bp)

 120596309 - 120602500

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065518 (version 83.38)

Entrez gene

 4710

UniProt

 O95168 (UniProt - Evidence at protein level)

neXtProt

 NX_O95168

Antibodypedia

 NDUFB4 antibodies

PROTEIN BROWSER
NDUFB4-001
NDUFB4-002
NDUFB4-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NDUFB4-001
ENSP00000184266
ENST00000184266
O95168 [Direct mapping]
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0006979 [response to oxidative stress]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0016021 [integral component of membrane]
GO:0022904 [respiratory electron transport chain]
GO:0031965 [nuclear membrane]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 129 aa
15.2 kDa 		No 1
NDUFB4-002
ENSP00000419578
ENST00000485064
O95168 [Direct mapping]
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0006979 [response to oxidative stress]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0016021 [integral component of membrane]
GO:0022904 [respiratory electron transport chain]
GO:0031965 [nuclear membrane]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 120 aa
14 kDa 		No 1
NDUFB4-006
ENSP00000419128
ENST00000492739
C9JXQ9 [Direct mapping]
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0031965 [nuclear membrane]
GO:0055114 [oxidation-reduction process]
Show all
 80 aa
9.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.