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MYLK

CANCER ATLAS

Gene description

 Myosin light chain kinase

Protein class

 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA031677
CAB020789

GENE INFORMATION

Gene name

 MYLK (HGNC Symbol)

Synonyms

 MLCK, MLCK1, MYLK1, smMLCK

Description

 Myosin light chain kinase (HGNC Symbol)

Entrez gene summary

 This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q21.1

Chromosome location (bp)

 123610049 - 123884331

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065534 (version 83.38)

Entrez gene

 4638

UniProt

 Q15746 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15746

Antibodypedia

 MYLK antibodies

PROTEIN BROWSER
MYLK-001
MYLK-003
MYLK-004
MYLK-009
MYLK-010
MYLK-018
MYLK-019
MYLK-201
MYLK-202
MYLK-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYLK-001
ENSP00000354004
ENST00000360772
Q15746 [Direct mapping]
Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007015 [actin filament organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014820 [tonic smooth muscle contraction]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0032060 [bleb assembly]
GO:0032154 [cleavage furrow]
GO:0046872 [metal ion binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0090303 [positive regulation of wound healing]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1863 aa
205.1 kDa 		No 0
MYLK-003
ENSP00000320622
ENST00000346322
Q15746 [Direct mapping]
Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007015 [actin filament organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014820 [tonic smooth muscle contraction]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0032060 [bleb assembly]
GO:0032154 [cleavage furrow]
GO:0046872 [metal ion binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0090303 [positive regulation of wound healing]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1845 aa
203.1 kDa 		No 1
MYLK-004
ENSP00000418335
ENST00000475616
Q15746 [Direct mapping]
Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007015 [actin filament organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014820 [tonic smooth muscle contraction]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0032060 [bleb assembly]
GO:0032154 [cleavage furrow]
GO:0046872 [metal ion binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0090303 [positive regulation of wound healing]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1914 aa
210.7 kDa 		No 1
MYLK-009
ENSP00000422984
ENST00000508240
D6R9C2 [Direct mapping]
Myosin light chain kinase, smooth muscle
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0006468 [protein phosphorylation]
GO:0006939 [smooth muscle contraction]
GO:0007015 [actin filament organization]
Show all
 229 aa
25.3 kDa 		No 0
MYLK-010
ENSP00000428967
ENST00000418370
Q15746 [Direct mapping]
Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003779 [actin binding]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007015 [actin filament organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014820 [tonic smooth muscle contraction]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0032060 [bleb assembly]
GO:0032154 [cleavage furrow]
GO:0046872 [metal ion binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0090303 [positive regulation of wound healing]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 154 aa
17 kDa 		No 0
MYLK-018
ENSP00000462118
ENST00000583087
Q15746 [Direct mapping]
Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003779 [actin binding]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007015 [actin filament organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014820 [tonic smooth muscle contraction]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0032060 [bleb assembly]
GO:0032154 [cleavage furrow]
GO:0046872 [metal ion binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0090303 [positive regulation of wound healing]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 154 aa
17 kDa 		No 0
MYLK-019
ENSP00000463691
ENST00000578202
Q15746 [Direct mapping]
Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003779 [actin binding]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007015 [actin filament organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014820 [tonic smooth muscle contraction]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0032060 [bleb assembly]
GO:0032154 [cleavage furrow]
GO:0046872 [metal ion binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0090303 [positive regulation of wound healing]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 153 aa
16.8 kDa 		No 0
MYLK-201
ENSP00000346846
ENST00000354792
Q15746 [Direct mapping]
Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007015 [actin filament organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014820 [tonic smooth muscle contraction]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0032060 [bleb assembly]
GO:0032154 [cleavage furrow]
GO:0046872 [metal ion binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0090303 [positive regulation of wound healing]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1845 aa
203.1 kDa 		No 1
MYLK-202
ENSP00000352088
ENST00000359169
Q15746 [Direct mapping]
Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007015 [actin filament organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014820 [tonic smooth muscle contraction]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0032060 [bleb assembly]
GO:0032154 [cleavage furrow]
GO:0046872 [metal ion binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0090303 [positive regulation of wound healing]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1863 aa
205.1 kDa 		No 0
MYLK-203
ENSP00000353452
ENST00000360304
Q15746 [Direct mapping]
Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0006936 [muscle contraction]
GO:0006939 [smooth muscle contraction]
GO:0007015 [actin filament organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014820 [tonic smooth muscle contraction]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0032060 [bleb assembly]
GO:0032154 [cleavage furrow]
GO:0046872 [metal ion binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0090303 [positive regulation of wound healing]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 1914 aa
210.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.