Tissue expression of SEC61A2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SEC61A2
Gene description	Sec61 translocon alpha 2 subunit
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SEC61A2 (HGNC Symbol)
Synonyms	FLJ10578
Description	Sec61 translocon alpha 2 subunit (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Chromosome	10
Cytoband	p14
Chromosome location (bp)	12129637 - 12169961
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065665 (version 83.38)
Entrez gene	55176
UniProt	Q9H9S3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H9S3
Antibodypedia	SEC61A2 antibodies

PROTEIN BROWSER

SEC61A2-001	SEC61A2-002	SEC61A2-003	SEC61A2-004	SEC61A2-008	SEC61A2-009	SEC61A2-010	SEC61A2-011	SEC61A2-014	SEC61A2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEC61A2-001 ENSP00000368302 ENST00000379017	A6NIF9 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	168 aa 18.5 kDa	No	4
SEC61A2-002 ENSP00000404959 ENST00000441368	C9JJV4 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	189 aa 21.5 kDa	No	4
SEC61A2-003 ENSP00000401731 ENST00000457034	H7C1Q9 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	94 aa 10.4 kDa	No	2
SEC61A2-004 ENSP00000393214 ENST00000418772	H7C069 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	145 aa 15.7 kDa	No	3
SEC61A2-008 ENSP00000302048 ENST00000304267	Q9H9S3 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 2 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0003674 [molecular_function] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0008150 [biological_process] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0044267 [cellular protein metabolic process] Show all	437 aa 48.8 kDa	No	8
SEC61A2-009 ENSP00000298428 ENST00000298428	Q9H9S3 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 2 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0003674 [molecular_function] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0008150 [biological_process] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0043022 [ribosome binding] GO:0044267 [cellular protein metabolic process] Show all	476 aa 52.2 kDa	No	9
SEC61A2-010 ENSP00000368306 ENST00000379020	F8W776 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	410 aa 44.7 kDa	No	9
SEC61A2-011 ENSP00000368339 ENST00000379051	A6NK38 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	159 aa 17.6 kDa	No	3
SEC61A2-014 ENSP00000402124 ENST00000419021	H7C1S8 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	228 aa 24.6 kDa	No	4
SEC61A2-201 ENSP00000368319 ENST00000379033	Q9H9S3 [Direct mapping] Protein transport protein Sec61 subunit alpha isoform 2 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0003674 [molecular_function] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0008150 [biological_process] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0044267 [cellular protein metabolic process] Show all	454 aa 49.6 kDa	No	8