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TLE2

CANCER ATLAS

Gene description

 Transducin-like enhancer of split 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049103

GENE INFORMATION

Gene name

 TLE2 (HGNC Symbol)

Synonyms

 ESG, ESG2, FLJ41188, GRG2

Description

 Transducin-like enhancer of split 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 2997638 - 3047635

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065717 (version 83.38)

Entrez gene

 7089

UniProt

 Q04725 (UniProt - Evidence at protein level)

neXtProt

 NX_Q04725

Antibodypedia

 TLE2 antibodies

PROTEIN BROWSER
«
TLE2-001
TLE2-002
TLE2-004
TLE2-006
TLE2-008
TLE2-015
TLE2-016
TLE2-017
TLE2-021
TLE2-201
TLE2-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TLE2-001
ENSP00000468279
ENST00000591529
Q04725 [Direct mapping]
Transducin-like enhancer protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007219 [Notch signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0016055 [Wnt signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 706 aa
75.4 kDa 		No 0
TLE2-002
ENSP00000392427
ENST00000443826
Q04725 [Direct mapping]
Transducin-like enhancer protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007219 [Notch signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0016055 [Wnt signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 621 aa
66.7 kDa 		No 0
TLE2-004
ENSP00000262953
ENST00000262953
Q04725 [Direct mapping]
Transducin-like enhancer protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007219 [Notch signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0016055 [Wnt signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 743 aa
79.8 kDa 		No 0
TLE2-006
ENSP00000466542
ENST00000590536
K7EMK7 [Direct mapping]
Transducin-like enhancer protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 744 aa
80 kDa 		No 0
TLE2-008
ENSP00000468666
ENST00000592584
K7ESD8 [Direct mapping]
Transducin-like enhancer protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 178 aa
19.8 kDa 		No 0
TLE2-015
ENSP00000467358
ENST00000587137
K7EPF3 [Direct mapping]
Transducin-like enhancer protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 140 aa
16 kDa 		No 0
TLE2-016
ENSP00000467337
ENST00000591457
K7EPD4 [Direct mapping]
Transducin-like enhancer protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 131 aa
14.8 kDa 		No 0
TLE2-017
ENSP00000465292
ENST00000589364
K7EJR7 [Direct mapping]
Transducin-like enhancer protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 280 aa
29.9 kDa 		No 0
TLE2-021
ENSP00000465519
ENST00000586422
K7EK93 [Direct mapping]
Transducin-like enhancer protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 119 aa
13.7 kDa 		No 0
TLE2-201
ENSP00000392869
ENST00000426948
Q04725 [Direct mapping]
Transducin-like enhancer protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007219 [Notch signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0016055 [Wnt signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 706 aa
75.4 kDa 		No 0
TLE2-202
ENSP00000413107
ENST00000455444
Q04725 [Direct mapping]
Transducin-like enhancer protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007219 [Notch signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0016055 [Wnt signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 621 aa
66.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.