Expression of TBC1D1 in cancer - Summary

CANCER ATLAS

Gene description

TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041816

GENE INFORMATION
Gene name	TBC1D1 (HGNC Symbol)
Synonyms	KIAA1108, TBC, TBC1
Description	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (HGNC Symbol)
Entrez gene summary	TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	p14
Chromosome location (bp)	37891087 - 38139175
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065882 (version 83.38)
Entrez gene	23216
UniProt	Q86TI0 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TI0
Antibodypedia	TBC1D1 antibodies

PROTEIN BROWSER

TBC1D1-001	TBC1D1-002	TBC1D1-006	TBC1D1-008	TBC1D1-009	TBC1D1-018	TBC1D1-019	TBC1D1-021	TBC1D1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBC1D1-001 ENSP00000261439 ENST00000261439	Q86TI0 [Direct mapping] TBC1 domain family member 1 B9A6J6 [Target identity:100%; Query identity:100%] TBC1 domain family, member 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0032880 [regulation of protein localization] GO:0043547 [positive regulation of GTPase activity] GO:0061024 [membrane organization] Show all	1168 aa 133.1 kDa	No	0
TBC1D1-002 ENSP00000383994 ENST00000402522	B5MCJ2 [Direct mapping] TBC1 domain family member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		144 aa 16.4 kDa	No	0
TBC1D1-006 ENSP00000396877 ENST00000446803	C9JIE2 [Direct mapping] TBC1 domain family member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	599 aa 67.3 kDa	No	0
TBC1D1-008 ENSP00000397640 ENST00000443855	H7C0Z7 [Direct mapping] TBC1 domain family member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		252 aa 27.5 kDa	No	0
TBC1D1-009 ENSP00000423651 ENST00000508802	Q86TI0 [Direct mapping] TBC1 domain family member 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0043547 [positive regulation of GTPase activity] GO:0061024 [membrane organization] Show all	1159 aa 131.4 kDa	No	0
TBC1D1-018 ENSP00000425655 ENST00000513936	H0YA01 [Direct mapping] TBC1 domain family member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		177 aa 20.1 kDa	No	0
TBC1D1-019 ENSP00000410167 ENST00000421339	H7C380 [Direct mapping] TBC1 domain family member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		226 aa 25.4 kDa	No	0
TBC1D1-021 ENSP00000421641 ENST00000510573	H0Y8P0 [Direct mapping] TBC1 domain family member 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		856 aa 97.8 kDa	No	0
TBC1D1-201 ENSP00000478039 ENST00000615497	A0JNU9 [Direct mapping] TBC1 domain family member 1; TBC1D1 protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		432 aa 50 kDa	No	0