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MTHFD2

GENERAL INFORMATION

Gene name

 MTHFD2

Gene description

 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissues, distinct expression in immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA049657 , CAB003684
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Appendix

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MTHFD2

Synonyms

Description

 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]

Chromosome

 2

Cytoband

 p13.1

Chromosome location (bp)

 74198562 - 74217565

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065911 (version 83.38)

Entrez gene

 10797

UniProt

 P13995 (UniProt - Evidence at protein level)

neXtProt

 NX_P13995

Antibodypedia

 MTHFD2 antibodies

PROTEIN BROWSER
MTHFD2-001
MTHFD2-003
MTHFD2-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTHFD2-001
ENSP00000377617
ENST00000394053
P13995 [Direct mapping]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase Methenyltetrahydrofolate cyclohydrolase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003824 [catalytic activity]
GO:0004477 [methenyltetrahydrofolate cyclohydrolase activity]
GO:0004487 [methylenetetrahydrofolate dehydrogenase (NAD+) activity]
GO:0004488 [methylenetetrahydrofolate dehydrogenase (NADP+) activity]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0006730 [one-carbon metabolic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0042301 [phosphate ion binding]
GO:0046653 [tetrahydrofolate metabolic process]
GO:0055114 [oxidation-reduction process]
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 350 aa
37.9 kDa 		Yes 0
MTHFD2-003
ENSP00000386536
ENST00000409804
B9A062 [Direct mapping]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004477 [methenyltetrahydrofolate cyclohydrolase activity]
GO:0004488 [methylenetetrahydrofolate dehydrogenase (NADP+) activity]
GO:0005739 [mitochondrion]
GO:0006730 [one-carbon metabolic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0055114 [oxidation-reduction process]
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 222 aa
23.9 kDa 		Yes 0
MTHFD2-009
ENSP00000386542
ENST00000409601
B8ZZU9 [Direct mapping]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004477 [methenyltetrahydrofolate cyclohydrolase activity]
GO:0004488 [methylenetetrahydrofolate dehydrogenase (NADP+) activity]
GO:0005739 [mitochondrion]
GO:0006730 [one-carbon metabolic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0055114 [oxidation-reduction process]
Show all
 267 aa
29 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.