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YBX1

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GENERAL INFORMATION

Gene name

 YBX1

Gene description

 Y box binding protein 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (validated)

Additional location

 In addition localized to the Vesicles (supported)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA040304 , HPA057159
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to vesicles.

Main location

 Cytosol (validated)

Additional location

 Vesicles (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA040304 A-431 Cytosol
HPA040304 U-2 OS Vesicles
Cytosol
HPA040304 U-251 MG Cytosol
HPA057159 A-431 Nuclear membrane
Vesicles
Cytosol
HPA057159 U-2 OS Nuclear membrane
Vesicles
Cytosol
HPA057159 U-251 MG Cytosol

GENE INFORMATION

Gene name

 YBX1 (HGNC Symbol)

Synonyms

 BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1

Description

 Y box binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 42682427 - 42702349

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065978 (version 83.38)

Entrez gene

 4904

UniProt

 P67809 (UniProt - Evidence at protein level)

neXtProt

 NX_P67809

Antibodypedia

 YBX1 antibodies

PROTEIN BROWSER
YBX1-001
YBX1-002
YBX1-004
YBX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
YBX1-001
ENSP00000361626
ENST00000321358
P67809 [Direct mapping]
Nuclease-sensitive element-binding protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   beta-Barrel DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001701 [in utero embryonic development]
GO:0002039 [p53 binding]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005689 [U12-type spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0030425 [dendrite]
GO:0030529 [ribonucleoprotein complex]
GO:0031965 [nuclear membrane]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051020 [GTPase binding]
GO:0051154 [negative regulation of striated muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0070062 [extracellular exosome]
GO:0070934 [CRD-mediated mRNA stabilization]
GO:0070937 [CRD-mediated mRNA stability complex]
GO:0071204 [histone pre-mRNA 3'end processing complex]
GO:1990124 [messenger ribonucleoprotein complex]
Show all
 324 aa
35.9 kDa 		No 0
YBX1-002
ENSP00000389639
ENST00000436427
H0Y449 [Direct mapping]
Nuclease-sensitive element-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 374 aa
41.9 kDa 		No 0
YBX1-004
ENSP00000405937
ENST00000332220
C9J5V9 [Direct mapping]
Nuclease-sensitive element-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 216 aa
23.6 kDa 		No 0
YBX1-201
ENSP00000484416
ENST00000616651
A0A087X1S2 [Direct mapping]
Nuclease-sensitive element-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 320 aa
34.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.