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Weak to moderate cytoplasmic staining was observed in the majority of cancers. Most cases of lymphomas, skin, testicular, renal and cervical cancers were negative.
Cancer tissues displayed moderate to strong cytoplasmic staining. Several cases of renal and liver cancers were weakly stained or negative.
GENE INFORMATION
Gene name
DIP2B (HGNC Symbol)
Synonyms
FLJ34278, KIAA1463
Description
Disco-interacting protein 2 homolog B (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]
