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NFYC

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GENERAL INFORMATION

Gene name

 NFYC

Gene description

 Nuclear transcription factor Y, gamma

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 19
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Mouse

 Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA055011
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA055011 MCF7 Nucleoplasm
HPA055011 PC-3 Nucleoplasm
HPA055011 U-2 OS Nucleoplasm

MOUSE CELLS

Main location

 Nucleoplasm

Mouse gene

 ENSMUSG00000032897 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA055011 NIH 3T3 Nucleoplasm

GENE INFORMATION

Gene name

 NFYC (HGNC Symbol)

Synonyms

 CBF-C, NF-YC

Description

 Nuclear transcription factor Y, gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 40691570 - 40771603

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066136 (version 83.38)

Entrez gene

 4802

UniProt

 Q13952 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13952

Antibodypedia

 NFYC antibodies

PROTEIN BROWSER
«
NFYC-001
NFYC-002
NFYC-003
NFYC-004
NFYC-005
NFYC-006
NFYC-007
NFYC-010
NFYC-011
NFYC-012
NFYC-015
NFYC-016
NFYC-017
NFYC-020
NFYC-021
NFYC-022
NFYC-024
NFYC-025
NFYC-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFYC-001
ENSP00000404427
ENST00000447388
Q13952 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
Show all
 335 aa
37.2 kDa 		No 0
NFYC-002
ENSP00000408315
ENST00000427410
Q13952 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
Show all
 297 aa
32.8 kDa 		No 0
NFYC-003
ENSP00000361737
ENST00000372653
Q13952 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
Show all
 301 aa
33.7 kDa 		No 0
NFYC-004
ENSP00000361736
ENST00000372652
Q13952 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
Show all
 439 aa
48.1 kDa 		No 0
NFYC-005
ENSP00000361738
ENST00000372654
Q13952 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
Show all
 335 aa
37.2 kDa 		No 0
NFYC-006
ENSP00000361734
ENST00000372651
Q13952 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
Show all
 335 aa
37.2 kDa 		No 0
NFYC-007
ENSP00000312617
ENST00000308733
Q13952 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
Show all
 458 aa
50.3 kDa 		No 0
NFYC-010
ENSP00000397647
ENST00000453631
Q5T6K7 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016602 [CCAAT-binding factor complex]
GO:0046982 [protein heterodimerization activity]
Show all
 129 aa
14.9 kDa 		No 0
NFYC-011
ENSP00000414299
ENST00000440226
Q13952 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
Show all
 335 aa
37.2 kDa 		No 0
NFYC-012
ENSP00000361754
ENST00000372669
Q5T6K5 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016602 [CCAAT-binding factor complex]
GO:0046982 [protein heterodimerization activity]
Show all
 313 aa
34.2 kDa 		No 0
NFYC-015
ENSP00000396620
ENST00000425457
Q13952 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0008134 [transcription factor binding]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 354 aa
39.3 kDa 		No 0
NFYC-016
ENSP00000416403
ENST00000414185
H0Y803 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016602 [CCAAT-binding factor complex]
Show all
 186 aa
20.4 kDa 		No 0
NFYC-017
ENSP00000408867
ENST00000456393
Q13952 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006457 [protein folding]
GO:0016602 [CCAAT-binding factor complex]
GO:0032993 [protein-DNA complex]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
Show all
 334 aa
37.1 kDa 		No 0
NFYC-020
ENSP00000433820
ENST00000534399
E9PJA8 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016602 [CCAAT-binding factor complex]
Show all
 52 aa
5.9 kDa 		No 0
NFYC-021
ENSP00000434404
ENST00000531464
E9PQR2 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016602 [CCAAT-binding factor complex]
GO:0046982 [protein heterodimerization activity]
Show all
 60 aa
6.9 kDa 		No 0
NFYC-022
ENSP00000436710
ENST00000525290
E9PI99 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016602 [CCAAT-binding factor complex]
GO:0046982 [protein heterodimerization activity]
Show all
 141 aa
16.2 kDa 		No 0
NFYC-024
ENSP00000433413
ENST00000530965
E9PL11 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016602 [CCAAT-binding factor complex]
GO:0046982 [protein heterodimerization activity]
Show all
 95 aa
10.8 kDa 		No 0
NFYC-025
ENSP00000409219
ENST00000416859
A0A0A0MT00 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016602 [CCAAT-binding factor complex]
GO:0046982 [protein heterodimerization activity]
Show all
 180 aa
20 kDa 		No 0
NFYC-201
ENSP00000480994
ENST00000620728
A0A087WXG1 [Direct mapping]
Nuclear transcription factor Y subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016602 [CCAAT-binding factor complex]
Show all
 233 aa
25.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.