Expression of SLC9A3 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036493	HPA036669

GENE INFORMATION
Gene name	SLC9A3 (HGNC Symbol)
Synonyms	NHE3
Description	Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	473310 - 524332
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000066230 (version 83.38)
Entrez gene	6550
UniProt	P48764 (UniProt - Evidence at protein level)
neXtProt	NX_P48764
Antibodypedia	SLC9A3 antibodies

PROTEIN BROWSER

SLC9A3-001	SLC9A3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC9A3-001 ENSP00000264938 ENST00000264938	P48764 [Direct mapping] Sodium/hydrogen exchanger 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002028 [regulation of sodium ion transport] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005903 [brush border] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0006898 [receptor-mediated endocytosis] GO:0007623 [circadian rhythm] GO:0009986 [cell surface] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030165 [PDZ domain binding] GO:0031526 [brush border membrane] GO:0031988 [membrane-bounded vesicle] GO:0035725 [sodium ion transmembrane transport] GO:0051384 [response to glucocorticoid] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902600 [hydrogen ion transmembrane transport] Show all	834 aa 92.9 kDa	Yes	>9
SLC9A3-003 ENSP00000422983 ENST00000514375	P48764 [Direct mapping] Sodium/hydrogen exchanger 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005903 [brush border] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0009986 [cell surface] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030165 [PDZ domain binding] GO:0031526 [brush border membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902600 [hydrogen ion transmembrane transport] Show all	825 aa 91.9 kDa	Yes	>9