Cell atlas - GOLGA5 - The Human Protein Atlas

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GOLGA5

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	GOLGA5
Gene description	Golgin A5
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA000992
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA000992	A-431	Golgi apparatus
	HPA000992	U-2 OS	Golgi apparatus
	HPA000992	U-251 MG	Golgi apparatus

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA000992	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. GOLGA5 localizes to the Golgi apparatus, but not to the cis-Golgi compartment.

GENE INFORMATION
Gene name	GOLGA5 (HGNC Symbol)
Synonyms	golgin-84, GOLIM5, ret-II, rfg5
Description	Golgin A5 (HGNC Symbol)
Entrez gene summary	The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]
Chromosome	14
Cytoband	q32.12
Chromosome location (bp)	92794231 - 92839963
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000066455 (version 83.38)
Entrez gene	9950
UniProt	Q8TBA6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TBA6
Antibodypedia	GOLGA5 antibodies

PROTEIN BROWSER

GOLGA5-001	GOLGA5-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GOLGA5-001 ENSP00000163416 ENST00000163416	Q8TBA6 [Direct mapping] Golgin subfamily A member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000137 [Golgi cis cisterna] GO:0000138 [Golgi trans cisterna] GO:0000139 [Golgi membrane] GO:0000301 [retrograde transport, vesicle recycling within Golgi] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005797 [Golgi medial cisterna] GO:0005801 [cis-Golgi network] GO:0007030 [Golgi organization] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017137 [Rab GTPase binding] GO:0030663 [COPI-coated vesicle membrane] GO:0030674 [protein binding, bridging] GO:0031985 [Golgi cisterna] GO:0042803 [protein homodimerization activity] GO:0048193 [Golgi vesicle transport] Show all	731 aa 83 kDa	No	1
GOLGA5-003 ENSP00000452601 ENST00000554700	H0YK03 [Direct mapping] Golgin subfamily A member 5 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		117 aa 12.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.