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The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]
Enzymes ENZYME proteins Lyases Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Lyases Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004325 [ferrochelatase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006091 [generation of precursor metabolites and energy] GO:0006778 [porphyrin-containing compound metabolic process] GO:0006779 [porphyrin-containing compound biosynthetic process] GO:0006783 [heme biosynthetic process] GO:0008198 [ferrous iron binding] GO:0008203 [cholesterol metabolic process] GO:0009416 [response to light stimulus] GO:0009589 [detection of UV] GO:0010038 [response to metal ion] GO:0010288 [response to lead ion] GO:0010468 [regulation of gene expression] GO:0010999 [regulation of eIF2 alpha phosphorylation by heme] GO:0017085 [response to insecticide] GO:0020037 [heme binding] GO:0030218 [erythrocyte differentiation] GO:0030350 [iron-responsive element binding] GO:0034379 [very-low-density lipoprotein particle assembly] GO:0042493 [response to drug] GO:0044281 [small molecule metabolic process] GO:0045471 [response to ethanol] GO:0046501 [protoporphyrinogen IX metabolic process] GO:0046685 [response to arsenic-containing substance] GO:0046906 [tetrapyrrole binding] GO:0046984 [regulation of hemoglobin biosynthetic process] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0051597 [response to methylmercury] GO:0055072 [iron ion homeostasis] GO:0070541 [response to platinum ion] GO:0071549 [cellular response to dexamethasone stimulus]