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SP100

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GENERAL INFORMATION

Gene name

 SP100

Gene description

 SP100 nuclear antigen

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear bodies. In addition localized to the nucleus.

RNA cell category

 Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (supported)

Additional location

 In addition localized to the Nucleus (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA017384
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear bodies. In addition localized to the nucleus.

Main location

 Nuclear bodies (supported)

Additional location

 Nucleus (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA017384 A-431 Nucleus
Nuclear bodies
HPA017384 U-2 OS Nucleus
Nuclear bodies
HPA017384 U-251 MG Nucleus
Nuclear bodies

GENE INFORMATION

Gene name

 SP100

Synonyms

Description

 SP100 nuclear antigen (HGNC Symbol)

Entrez gene summary

 This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 230415942 - 230544090

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000067066 (version 83.38)

Entrez gene

 6672

UniProt

 P23497 (UniProt - Evidence at protein level)

neXtProt

 NX_P23497

Antibodypedia

 SP100 antibodies

PROTEIN BROWSER
«
SP100-001
SP100-002
SP100-003
SP100-004
SP100-005
SP100-006
SP100-008
SP100-010
SP100-016
SP100-017
SP100-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SP100-001
ENSP00000264052
ENST00000264052
P23497 [Direct mapping]
Nuclear autoantigen Sp-100
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000723 [telomere maintenance]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0008134 [transcription factor binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019900 [kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030870 [Mre11 complex]
GO:0032526 [response to retinoic acid]
GO:0032897 [negative regulation of viral transcription]
GO:0034097 [response to cytokine]
GO:0034340 [response to type I interferon]
GO:0034341 [response to interferon-gamma]
GO:0034399 [nuclear periphery]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051271 [negative regulation of cellular component movement]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0070087 [chromo shadow domain binding]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902044 [regulation of Fas signaling pathway]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 879 aa
100.4 kDa 		No 0
SP100-002
ENSP00000343023
ENST00000340126
P23497 [Direct mapping]
Nuclear autoantigen Sp-100
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000723 [telomere maintenance]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019900 [kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030870 [Mre11 complex]
GO:0032526 [response to retinoic acid]
GO:0032897 [negative regulation of viral transcription]
GO:0034097 [response to cytokine]
GO:0034340 [response to type I interferon]
GO:0034341 [response to interferon-gamma]
GO:0034399 [nuclear periphery]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051271 [negative regulation of cellular component movement]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0070087 [chromo shadow domain binding]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902044 [regulation of Fas signaling pathway]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 885 aa
101.6 kDa 		No 0
SP100-003
ENSP00000393679
ENST00000431952
H0Y4R8 [Direct mapping]
Nuclear autoantigen Sp-100
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0006338 [chromatin remodeling]
GO:0008270 [zinc ion binding]
Show all
 259 aa
30.6 kDa 		No 0
SP100-004
ENSP00000386427
ENST00000409112
P23497 [Direct mapping]
Nuclear autoantigen Sp-100
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000723 [telomere maintenance]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0008134 [transcription factor binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019900 [kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030870 [Mre11 complex]
GO:0032526 [response to retinoic acid]
GO:0032897 [negative regulation of viral transcription]
GO:0034097 [response to cytokine]
GO:0034340 [response to type I interferon]
GO:0034341 [response to interferon-gamma]
GO:0034399 [nuclear periphery]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051271 [negative regulation of cellular component movement]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0070087 [chromo shadow domain binding]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902044 [regulation of Fas signaling pathway]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 688 aa
78.2 kDa 		No 0
SP100-005
ENSP00000386998
ENST00000409897
P23497 [Direct mapping]
Nuclear autoantigen Sp-100
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000723 [telomere maintenance]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0008134 [transcription factor binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019900 [kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030870 [Mre11 complex]
GO:0032526 [response to retinoic acid]
GO:0032897 [negative regulation of viral transcription]
GO:0034097 [response to cytokine]
GO:0034340 [response to type I interferon]
GO:0034341 [response to interferon-gamma]
GO:0034399 [nuclear periphery]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051271 [negative regulation of cellular component movement]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0070087 [chromo shadow domain binding]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902044 [regulation of Fas signaling pathway]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 445 aa
50 kDa 		No 0
SP100-006
ENSP00000386404
ENST00000409341
P23497 [Direct mapping]
Nuclear autoantigen Sp-100
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000723 [telomere maintenance]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0008134 [transcription factor binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019900 [kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030870 [Mre11 complex]
GO:0032526 [response to retinoic acid]
GO:0032897 [negative regulation of viral transcription]
GO:0034097 [response to cytokine]
GO:0034340 [response to type I interferon]
GO:0034341 [response to interferon-gamma]
GO:0034399 [nuclear periphery]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051271 [negative regulation of cellular component movement]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0070087 [chromo shadow domain binding]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902044 [regulation of Fas signaling pathway]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 480 aa
53.8 kDa 		No 0
SP100-008
ENSP00000387311
ENST00000409824
E9PHV6 [Direct mapping]
Nuclear autoantigen Sp-100
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
Show all
 455 aa
50.9 kDa 		No 0
SP100-010
ENSP00000391616
ENST00000432979
C9JBL0 [Direct mapping]
Nuclear autoantigen Sp-100
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
Show all
 193 aa
22 kDa 		No 0
SP100-016
ENSP00000400277
ENST00000413284
H7C1G8 [Direct mapping]
Nuclear autoantigen Sp-100
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0006338 [chromatin remodeling]
Show all
 126 aa
13.9 kDa 		No 0
SP100-017
ENSP00000416563
ENST00000452345
H7C4B4 [Direct mapping]
Nuclear autoantigen Sp-100
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0006338 [chromatin remodeling]
Show all
 193 aa
21.8 kDa 		No 0
SP100-201
ENSP00000399389
ENST00000427101
P23497 [Direct mapping]
Nuclear autoantigen Sp-100
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000723 [telomere maintenance]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0008134 [transcription factor binding]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019900 [kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030870 [Mre11 complex]
GO:0032526 [response to retinoic acid]
GO:0032897 [negative regulation of viral transcription]
GO:0034097 [response to cytokine]
GO:0034340 [response to type I interferon]
GO:0034341 [response to interferon-gamma]
GO:0034399 [nuclear periphery]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051271 [negative regulation of cellular component movement]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0070087 [chromo shadow domain binding]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902044 [regulation of Fas signaling pathway]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 452 aa
50.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.