Expression of TRAM1 in cancer - Summary

CANCER ATLAS

Gene description

Translocation associated membrane protein 1

Protein class

Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA023929

GENE INFORMATION
Gene name	TRAM1 (HGNC Symbol)
Synonyms	TRAM, TRAMP
Description	Translocation associated membrane protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]
Chromosome	8
Cytoband	q13.3
Chromosome location (bp)	70573442 - 70608387
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067167 (version 83.38)
Entrez gene	23471
UniProt	Q15629 (UniProt - Evidence at protein level)
neXtProt	NX_Q15629
Antibodypedia	TRAM1 antibodies

PROTEIN BROWSER

TRAM1-001	TRAM1-002	TRAM1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRAM1-001 ENSP00000262213 ENST00000262213	Q15629 [Direct mapping] Translocating chain-associated membrane protein 1 Q6FHL3 [Target identity:100%; Query identity:100%] Translocating chain-associated membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006412 [translation] GO:0006613 [cotranslational protein targeting to membrane] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0044267 [cellular protein metabolic process] Show all	374 aa 43.1 kDa	No	8
TRAM1-002 ENSP00000428052 ENST00000521425	G3XAN4 [Direct mapping] Translocating chain-associated membrane protein 1; Translocation associated membrane protein 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	288 aa 33.4 kDa	No	6
TRAM1-004 ENSP00000428025 ENST00000518678	E5RFP8 [Direct mapping] Translocating chain-associated membrane protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	112 aa 12.9 kDa	No	2