Cell atlas - ZFY - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ZFY
Gene description	Zinc finger protein, Y-linked
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Nucleoli (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071863
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (approved)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA071863	HeLa	Nucleoplasm
HPA071863	SiHa	Nucleoplasm
HPA071863	U-2 OS	Nucleoplasm
HPA071863	U-2 OS	Nucleoli	Intensity

GENE INFORMATION
Gene name	ZFY (HGNC Symbol)
Synonyms	ZNF911
Description	Zinc finger protein, Y-linked (HGNC Symbol)
Entrez gene summary	This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]
Chromosome	Y
Cytoband	p11.2
Chromosome location (bp)	2935281 - 2982506
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067646 (version 83.38)
Entrez gene	7544
UniProt	P08048 (UniProt - Evidence at protein level)
neXtProt	NX_P08048
Antibodypedia	ZFY antibodies

PROTEIN BROWSER

ZFY-001	ZFY-002	ZFY-005	ZFY-006	ZFY-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZFY-001 ENSP00000372525 ENST00000383052	P08048 [Direct mapping] Zinc finger Y-chromosomal protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0046872 [metal ion binding] Show all	801 aa 90.5 kDa	No	0
ZFY-002 ENSP00000388814 ENST00000443793	C9JQM1 [Direct mapping] Zinc finger Y-chromosomal protein Show all	Predicted intracellular proteins Show all		91 aa 10.1 kDa	No	0
ZFY-005 ENSP00000393908 ENST00000449237	P08048 [Direct mapping] Zinc finger Y-chromosomal protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0046872 [metal ion binding] Show all	724 aa 82.2 kDa	No	0
ZFY-006 ENSP00000485605 ENST00000625061	P08048 [Direct mapping] Zinc finger Y-chromosomal protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0046872 [metal ion binding] Show all	610 aa 69.9 kDa	No	0
ZFY-201 ENSP00000155093 ENST00000155093	P08048 [Direct mapping] Zinc finger Y-chromosomal protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0046872 [metal ion binding] Show all	801 aa 90.5 kDa	No	0