Cell atlas - NAV3 - The Human Protein Atlas

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NAV3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear membrane

Human cell
	Cytosol
	Nuclear membrane

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GENERAL INFORMATION
Gene name	NAV3
Gene description	Neuron navigator 3
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (WM-115, U-138 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA032111
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (WM-115, U-138 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane. In addition localized to the cytosol.

Main location

Nuclear membrane (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA032111	A-431	Nuclear membrane
	HPA032111	A-431	Cytosol
	HPA032111	U-2 OS	Nuclear membrane
	HPA032111	U-2 OS	Cytosol
	HPA032111	U-251 MG	Nuclear membrane
	HPA032111	U-251 MG	Cytosol

GENE INFORMATION
Gene name	NAV3 (HGNC Symbol)
Synonyms	KIAA0938, POMFIL1
Description	Neuron navigator 3 (HGNC Symbol)
Entrez gene summary	This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q21.2
Chromosome location (bp)	77830905 - 78213008
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067798 (version 83.38)
Entrez gene	89795
UniProt	Q8IVL0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVL0
Antibodypedia	NAV3 antibodies

PROTEIN BROWSER

NAV3-001	NAV3-002	NAV3-003	NAV3-004	NAV3-005	NAV3-006	NAV3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAV3-001 ENSP00000381007 ENST00000397909	Q8IVL0 [Direct mapping] Neuron navigator 3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005640 [nuclear outer membrane] Show all	2385 aa 255.6 kDa	No	0
NAV3-002 ENSP00000446628 ENST00000549464	F8VZV4 [Direct mapping] Neuron navigator 3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	679 aa 72 kDa	No	0
NAV3-003 ENSP00000446132 ENST00000536525	Q8IVL0 [Direct mapping] Neuron navigator 3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005640 [nuclear outer membrane] Show all	2363 aa 253 kDa	No	0
NAV3-004 ENSP00000446644 ENST00000552895	H0YHA8 [Direct mapping] Neuron navigator 3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	1258 aa 135.9 kDa	No	0
NAV3-005 ENSP00000448303 ENST00000550788	H0YI14 [Direct mapping] Neuron navigator 3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	799 aa 87.2 kDa	No	0
NAV3-006 ENSP00000448243 ENST00000551162	H0YI04 [Direct mapping] Neuron navigator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		253 aa 28.9 kDa	No	1
NAV3-010 ENSP00000448037 ENST00000550503	H0YHX7 [Direct mapping] Neuron navigator 3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	233 aa 24.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.