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A majority of cancer tissues showed moderate cytoplasmic staining with a granular pattern. Strong immunoreactivity was observed in few colorectal- and thyroid cancers.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0004449 [isocitrate dehydrogenase (NAD+) activity] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006099 [tricarboxylic acid cycle] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0004449 [isocitrate dehydrogenase (NAD+) activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005975 [carbohydrate metabolic process] GO:0006099 [tricarboxylic acid cycle] GO:0006102 [isocitrate metabolic process] GO:0006103 [2-oxoglutarate metabolic process] GO:0006734 [NADH metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045926 [negative regulation of growth] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0004449 [isocitrate dehydrogenase (NAD+) activity] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006099 [tricarboxylic acid cycle] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0004449 [isocitrate dehydrogenase (NAD+) activity] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006099 [tricarboxylic acid cycle] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
SCAMPI predicted membrane proteins Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0004449 [isocitrate dehydrogenase (NAD+) activity] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006099 [tricarboxylic acid cycle] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
