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Rho-associated, coiled-coil containing protein kinase 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Q13464 [Direct mapping] Rho-associated protein kinase 1
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0001726 [ruffle] GO:0003383 [apical constriction] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0006939 [smooth muscle contraction] GO:0007159 [leukocyte cell-cell adhesion] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007264 [small GTPase mediated signal transduction] GO:0007266 [Rho protein signal transduction] GO:0007411 [axon guidance] GO:0012501 [programmed cell death] GO:0016525 [negative regulation of angiogenesis] GO:0017048 [Rho GTPase binding] GO:0022614 [membrane to membrane docking] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0030155 [regulation of cell adhesion] GO:0030866 [cortical actin cytoskeleton organization] GO:0032059 [bleb] GO:0032060 [bleb assembly] GO:0032091 [negative regulation of protein binding] GO:0032956 [regulation of actin cytoskeleton organization] GO:0032970 [regulation of actin filament-based process] GO:0035509 [negative regulation of myosin-light-chain-phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045616 [regulation of keratinocyte differentiation] GO:0046872 [metal ion binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0050901 [leukocyte tethering or rolling] GO:0051451 [myoblast migration] GO:0051492 [regulation of stress fiber assembly] GO:0051893 [regulation of focal adhesion assembly] GO:0051894 [positive regulation of focal adhesion assembly] GO:0090002 [establishment of protein localization to plasma membrane] GO:1903140 [regulation of establishment of endothelial barrier] GO:1903347 [negative regulation of bicellular tight junction assembly] GO:2000114 [regulation of establishment of cell polarity] GO:2000145 [regulation of cell motility]
