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HYAL2

CANCER ATLAS

Gene description

 Hyaluronoglucosaminidase 2

Protein class

 Enzymes, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036436

GENE INFORMATION

Gene name

 HYAL2 (HGNC Symbol)

Synonyms

 LuCa-2, LUCA2

Description

 Hyaluronoglucosaminidase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 50317790 - 50322906

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068001 (version 83.38)

Entrez gene

 8692

UniProt

 Q12891 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12891

Antibodypedia

 HYAL2 antibodies

PROTEIN BROWSER
HYAL2-001
HYAL2-002
HYAL2-003
HYAL2-004
HYAL2-006
HYAL2-007
HYAL2-008
HYAL2-009
HYAL2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HYAL2-001
ENSP00000350387
ENST00000357750
Q12891 [Direct mapping]
Hyaluronidase-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000302 [response to reactive oxygen species]
GO:0001618 [virus receptor activity]
GO:0001822 [kidney development]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0009615 [response to virus]
GO:0009986 [cell surface]
GO:0010764 [negative regulation of fibroblast migration]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016324 [apical plasma membrane]
GO:0019064 [fusion of virus membrane with host plasma membrane]
GO:0019087 [transformation of host cell by virus]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030294 [receptor signaling protein tyrosine kinase inhibitor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0033906 [hyaluronoglucuronidase activity]
GO:0035810 [positive regulation of urine volume]
GO:0042117 [monocyte activation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045121 [membrane raft]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046658 [anchored component of plasma membrane]
GO:0046677 [response to antibiotic]
GO:0046718 [viral entry into host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050431 [transforming growth factor beta binding]
GO:0050729 [positive regulation of inflammatory response]
GO:0051216 [cartilage development]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070295 [renal water absorption]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071493 [cellular response to UV-B]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000484 [positive regulation of interleukin-8 secretion]
GO:2000778 [positive regulation of interleukin-6 secretion]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 473 aa
53.9 kDa 		Yes 1
HYAL2-002
ENSP00000378571
ENST00000395139
Q12891 [Direct mapping]
Hyaluronidase-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0000302 [response to reactive oxygen species]
GO:0001618 [virus receptor activity]
GO:0001822 [kidney development]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0009615 [response to virus]
GO:0009986 [cell surface]
GO:0010764 [negative regulation of fibroblast migration]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016324 [apical plasma membrane]
GO:0019064 [fusion of virus membrane with host plasma membrane]
GO:0019087 [transformation of host cell by virus]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030294 [receptor signaling protein tyrosine kinase inhibitor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0033906 [hyaluronoglucuronidase activity]
GO:0035810 [positive regulation of urine volume]
GO:0042117 [monocyte activation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045121 [membrane raft]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046658 [anchored component of plasma membrane]
GO:0046677 [response to antibiotic]
GO:0046718 [viral entry into host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050431 [transforming growth factor beta binding]
GO:0050729 [positive regulation of inflammatory response]
GO:0051216 [cartilage development]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070295 [renal water absorption]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071493 [cellular response to UV-B]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000484 [positive regulation of interleukin-8 secretion]
GO:2000778 [positive regulation of interleukin-6 secretion]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 473 aa
53.9 kDa 		Yes 1
HYAL2-003
ENSP00000401853
ENST00000447092
Q12891 [Direct mapping]
Hyaluronidase-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0000302 [response to reactive oxygen species]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0001618 [virus receptor activity]
GO:0001822 [kidney development]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0009615 [response to virus]
GO:0009986 [cell surface]
GO:0010259 [multicellular organismal aging]
GO:0010764 [negative regulation of fibroblast migration]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016324 [apical plasma membrane]
GO:0019064 [fusion of virus membrane with host plasma membrane]
GO:0019087 [transformation of host cell by virus]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030294 [receptor signaling protein tyrosine kinase inhibitor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0033906 [hyaluronoglucuronidase activity]
GO:0035810 [positive regulation of urine volume]
GO:0042117 [monocyte activation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045121 [membrane raft]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046658 [anchored component of plasma membrane]
GO:0046677 [response to antibiotic]
GO:0046718 [viral entry into host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048705 [skeletal system morphogenesis]
GO:0050431 [transforming growth factor beta binding]
GO:0050729 [positive regulation of inflammatory response]
GO:0051216 [cartilage development]
GO:0051607 [defense response to virus]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060586 [multicellular organismal iron ion homeostasis]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070295 [renal water absorption]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071493 [cellular response to UV-B]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000484 [positive regulation of interleukin-8 secretion]
GO:2000778 [positive regulation of interleukin-6 secretion]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 473 aa
53.9 kDa 		Yes 1
HYAL2-004
ENSP00000406657
ENST00000442581
Q12891 [Direct mapping]
Hyaluronidase-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000302 [response to reactive oxygen species]
GO:0001618 [virus receptor activity]
GO:0001822 [kidney development]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0009615 [response to virus]
GO:0009986 [cell surface]
GO:0010764 [negative regulation of fibroblast migration]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016324 [apical plasma membrane]
GO:0019064 [fusion of virus membrane with host plasma membrane]
GO:0019087 [transformation of host cell by virus]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030294 [receptor signaling protein tyrosine kinase inhibitor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0033906 [hyaluronoglucuronidase activity]
GO:0035810 [positive regulation of urine volume]
GO:0042117 [monocyte activation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045121 [membrane raft]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046658 [anchored component of plasma membrane]
GO:0046677 [response to antibiotic]
GO:0046718 [viral entry into host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050431 [transforming growth factor beta binding]
GO:0050729 [positive regulation of inflammatory response]
GO:0051216 [cartilage development]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070295 [renal water absorption]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071493 [cellular response to UV-B]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000484 [positive regulation of interleukin-8 secretion]
GO:2000778 [positive regulation of interleukin-6 secretion]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 473 aa
53.9 kDa 		Yes 1
HYAL2-006
ENSP00000414656
ENST00000428028
C9JSI7 [Direct mapping]
Hyaluronidase
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005975 [carbohydrate metabolic process]
Show all
 76 aa
8.1 kDa 		Yes 0
HYAL2-007
ENSP00000399677
ENST00000458018
C9K016 [Direct mapping]
Hyaluronidase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005975 [carbohydrate metabolic process]
Show all
 121 aa
13.5 kDa 		Yes 0
HYAL2-008
ENSP00000398714
ENST00000424190
C9JBF5 [Direct mapping]
Hyaluronidase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005975 [carbohydrate metabolic process]
Show all
 117 aa
12.9 kDa 		Yes 0
HYAL2-009
ENSP00000405855
ENST00000415028
C9J700 [Direct mapping]
Hyaluronidase-2
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005975 [carbohydrate metabolic process]
Show all
 48 aa
5.1 kDa 		Yes 0
HYAL2-010
ENSP00000409642
ENST00000426286
C9JSD1 [Direct mapping]
Hyaluronidase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005975 [carbohydrate metabolic process]
Show all
 81 aa
8.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.