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TFE3

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GENERAL INFORMATION

Gene name

 TFE3

Gene description

 Transcription factor binding to IGHM enhancer 3

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA023881
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (supported), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA023881 A-431 Nucleoplasm
Cytosol
HPA023881 U-2 OS Nucleoplasm
Cytosol
HPA023881 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 TFE3 (HGNC Symbol)

Synonyms

 bHLHe33, TFEA

Description

 Transcription factor binding to IGHM enhancer 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 49028726 - 49043486

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068323 (version 83.38)

Entrez gene

 7030

UniProt

 P19532 (UniProt - Evidence at protein level)

neXtProt

 NX_P19532

Antibodypedia

 TFE3 antibodies

PROTEIN BROWSER
TFE3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TFE3-001
ENSP00000314129
ENST00000315869
P19532 [Direct mapping]
Transcription factor E3
A0A024QZ23 [Target identity:100%; Query identity:100%]
Transcription factor binding to IGHM enhancer 3, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002250 [adaptive immune response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006959 [humoral immune response]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045785 [positive regulation of cell adhesion]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
Show all
 575 aa
61.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.