Cell atlas - ACSL4 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ACSL4

premium

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Mitochondria

Human cell
	Golgi Apparatus
	Mitochondria

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ACSL4
Gene description	Acyl-CoA synthetase long-chain family member 4
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the mitochondria.
RNA cell category	Cell line enhanced (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved)
Additional location	In addition localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA000286
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the mitochondria.

Main location

Golgi apparatus (approved)

Additional location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA000286	A-431	Golgi apparatus
	HPA000286	U-2 OS	Golgi apparatus
	HPA000286	U-2 OS	Mitochondria
	HPA000286	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	ACSL4 (HGNC Symbol)
Synonyms	ACS4, FACL4, LACS4, MRX63, MRX68
Description	Acyl-CoA synthetase long-chain family member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q23
Chromosome location (bp)	109624244 - 109733403
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000068366 (version 83.38)
Entrez gene	2182
UniProt	O60488 (UniProt - Evidence at protein level)
neXtProt	NX_O60488
Antibodypedia	ACSL4 antibodies

PROTEIN BROWSER

ACSL4-001	ACSL4-002	ACSL4-003	ACSL4-006	ACSL4-007	ACSL4-008	ACSL4-009	ACSL4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSL4-001 ENSP00000262835 ENST00000348502	O60488 [Direct mapping] Long-chain-fatty-acid--CoA ligase 4 Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0008610 [lipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0030307 [positive regulation of cell growth] GO:0031957 [very long-chain fatty acid-CoA ligase activity] GO:0032307 [negative regulation of prostaglandin secretion] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0044233 [ER-mitochondrion membrane contact site] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0047676 [arachidonate-CoA ligase activity] GO:0070062 [extracellular exosome] Show all	670 aa 74.4 kDa	No	0
ACSL4-002 ENSP00000423077 ENST00000469857	A0A0C4DGB7 [Direct mapping] Long-chain-fatty-acid--CoA ligase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	54 aa 6.2 kDa	No	1
ACSL4-003 ENSP00000419171 ENST00000469796	O60488 [Direct mapping] Long-chain-fatty-acid--CoA ligase 4 Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0008610 [lipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0030307 [positive regulation of cell growth] GO:0031957 [very long-chain fatty acid-CoA ligase activity] GO:0032307 [negative regulation of prostaglandin secretion] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0044233 [ER-mitochondrion membrane contact site] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0047676 [arachidonate-CoA ligase activity] GO:0070062 [extracellular exosome] Show all	711 aa 79.2 kDa	No	3
ACSL4-006 ENSP00000425378 ENST00000508092	D6RDA8 [Direct mapping] Long-chain-fatty-acid--CoA ligase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	128 aa 14.6 kDa	No	1
ACSL4-007 ENSP00000425408 ENST00000502391	D6RD96 [Direct mapping] Long-chain-fatty-acid--CoA ligase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	145 aa 16.4 kDa	No	1
ACSL4-008 ENSP00000424808 ENST00000505855	D6RF95 [Direct mapping] Long-chain-fatty-acid--CoA ligase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	154 aa 17.2 kDa	No	0
ACSL4-009 ENSP00000421425 ENST00000504980	D6RFW9 [Direct mapping] Long-chain-fatty-acid--CoA ligase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	126 aa 14.3 kDa	No	1
ACSL4-201 ENSP00000339787 ENST00000340800	O60488 [Direct mapping] Long-chain-fatty-acid--CoA ligase 4 Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0006629 [lipid metabolic process] GO:0006641 [triglyceride metabolic process] GO:0007584 [response to nutrient] GO:0008152 [metabolic process] GO:0008610 [lipid biosynthetic process] GO:0015908 [fatty acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0030182 [neuron differentiation] GO:0030307 [positive regulation of cell growth] GO:0031957 [very long-chain fatty acid-CoA ligase activity] GO:0031966 [mitochondrial membrane] GO:0032307 [negative regulation of prostaglandin secretion] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0043025 [neuronal cell body] GO:0044233 [ER-mitochondrion membrane contact site] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0047676 [arachidonate-CoA ligase activity] GO:0060136 [embryonic process involved in female pregnancy] GO:0060996 [dendritic spine development] GO:0070062 [extracellular exosome] GO:0070672 [response to interleukin-15] Show all	711 aa 79.2 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.