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Several liver, renal, pancreatic and endometrial cancers showed moderate cytoplasmic positivity. Remaining cancer tissues were in general weakly stained or negative.
Cancer tissues generally displayed moderate cytoplasmic positivity. Additional membranous staining was observed in colorectal, pancreatic, liver and stomach cancers. A majority of gliomas, prostate, renal and endometrial cancers were weakly stained or negative.
GENE INFORMATION
Gene name
LAPTM4A (HGNC Symbol)
Synonyms
HUMORF13, KIAA0108, LAPTM4, MBNT, Mtrp
Description
Lysosomal protein transmembrane 4 alpha (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]